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ABSTRAKMerokok merupakan masalah kesehatan serius di seluruh dunia. Jumlah
perokok di Indonesia diperkirakan mencapai sepertiga dari jumlah seluruh
penduduk Indonesia, dan sebagian besar memulai merokok pada usia muda.
Merokok dapat menyebabkan kerusakan oksidatif pada jaringan dalam berbagai
tingkatan akibat meningkatnya radikal bebas dan menurunnya mekanisme
antioksidan baik tipe enzimatik maupun non-enzimatik. Banyak penelitian di
bidang akupunktur yang dilakukan untuk meneliti efek akupunktur terhadap kadar
enzim antioksidan dalam tubuh. Metoda akupunktur manual dan
elektroakupunktur frekuensi rendah kerap dilakukan oleh praktisi akupunktur
dalam praktek klinik. Penelitian ini bertujuan untuk mengetahui efek dari metode
penusukan akupunktur secara manual dan elektroakupunktur frekuensi rendah
terhadap peningkatan aktivitas enzim antioksidan Glutation peroksidase (GSHPx)
di plasma darah. Desain penelitian yang digunakan adalah uji klinis acak
tersamar ganda dengan kontrol. Penelitian ini melibatkan 42 subjek perokok yang
dibagi menjadi 2 kelompok yaitu kelompok akupunktur manual (n=21) dan
kelompok elektroakupunktur frekuensi rendah (n=21). Akupunktur dilakukan
pada titik ST36 Zusanli dan SP6 Sanyinjiao bilateral. Hasil penelitian
menunjukkan adanya peningkatan kadar Glutation peroksidase (GSH-Px) yang
bermakna pada kelompok akupunktur manual setelah terapi ke-3. Peningkatan
kadar GPx juga terjadi di kelompok elektroakupunktur frekuensi rendah namun
tidak bermakna secara statistik. Tidak terdapat perbedaan bermakna pada rerata
perubahan kadar Glutation Peroksidase pada kelompok akupunktur manual
dibandingkan dengan kelompok elektroakupunktur setelah terapi ke-3 (p=0.176).
Kesimpulan penelitian ini adalah akupunktur manual lebih efektif untuk
meningkatkan kadar enzim Glutation peroksidase daripada elektroakupunktur
frekuensi rendah.
ABSTRACTCigarette moking is a worldwide serious health problem. Smoking
prevalence in Indonesia is approximately one third of all population, and most of
them start to smoke since very young age. Smoking can cause oxidative damage
in body tissues in various levels due to the increase of free radicals and the
decrease of antioxidant mechanisms of enzymatic and non-enzymatic reactions.
Many trials have been conducted to find the acupuncture effect on antioxidant
enzymes in the body. Manual acupuncture and low frequency electroacupuncture
are often used by acupuncture professionals in clinical practice. The aim of this
study is to determine the effect of manual acupuncture and low frequency
electroacupuncture on serum levels of Gluthatione peroxidase (GSH-Px). The
design of the trial is a double-blind randomized controlled trial, involving 42
smokers which randomly allocated into groups of manual acupuncture (n=21) and
low frequency electroacupuncture (n=21). Acupuncture was conducted at ST 36
Zusanli dan SP 6 Sanyinjiao bilaterally. The results showed a significant increase
of serum Glutathione peroxidase on manual acupuncture group after the 3rd
treatment. The increase of serum Glutathione peroxidase was also shown on low
frequency electroacupuncture group, but not statistically significant. There was no
significant differences on the mean difference of Glutathione peroxidase levels in
manual acupuncture group and electroacupucture group after the 3rd treatment
(p=0.176). Conclusion of this study is manual acupuncture found to be more
effective in increasing the serum levels of GSH-Px than low frequency
electroacupuncture., Cigarette moking is a worldwide serious health problem. Smoking
prevalence in Indonesia is approximately one third of all population, and most of
them start to smoke since very young age. Smoking can cause oxidative damage
in body tissues in various levels due to the increase of free radicals and the
decrease of antioxidant mechanisms of enzymatic and non-enzymatic reactions.
Many trials have been conducted to find the acupuncture effect on antioxidant
enzymes in the body. Manual acupuncture and low frequency electroacupuncture
are often used by acupuncture professionals in clinical practice. The aim of this
study is to determine the effect of manual acupuncture and low frequency
electroacupuncture on serum levels of Gluthatione peroxidase (GSH-Px). The
design of the trial is a double-blind randomized controlled trial, involving 42
smokers which randomly allocated into groups of manual acupuncture (n=21) and
low frequency electroacupuncture (n=21). Acupuncture was conducted at ST 36
Zusanli dan SP 6 Sanyinjiao bilaterally. The results showed a significant increase
of serum Glutathione peroxidase on manual acupuncture group after the 3rd
treatment. The increase of serum Glutathione peroxidase was also shown on low
frequency electroacupuncture group, but not statistically significant. There was no
significant differences on the mean difference of Glutathione peroxidase levels in
manual acupuncture group and electroacupucture group after the 3rd treatment
(p=0.176). Conclusion of this study is manual acupuncture found to be more
effective in increasing the serum levels of GSH-Px than low frequency
electroacupuncture.]
T-Airine Hendrawan.pdf :: Unduh