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ABSTRAKTujuan: Untuk mengevaluasi pengaruh pemberian suplementasi Mirtogenol terhadap perubahan ketebalan lapisan serabut saraf retina dan lapang pandang pada pasien dengan glaukoma primer sudut terbuka (GPSTa) dengan tekanan intraokular (TIO) terkontrol.
Metode: Penelitian ini merupakan penelitian prospektif, acak, tersamar ganda. Empat puluh satu pasien dengan GPSTa dengan TIO ≤ 18 mmHg diacak untuk mendapatkan Mirtogenol atau plasebo. Perubahan ketebalan RNFL dan MD lapang pandang diperiksa sebelum penelitian, 4 minggu serta 8 minggu setelah pemberian obat. Efek samping pengobatan ditanyakan kepada pasien selama penelitian.
Hasil: Rerata ketebalan RNFL kelompok Mirtogenol mengalami penurunan sebesar -0.70±1.63 μm dari 87.29±19.39 μm di awal penelitian menjadi 86.58±19.43 μm setelah 8 minggu, namun perubahan yang terjadi tidak bermakna secara statistik (p=0.121). Rerata ketebalan RNFL kelompok plasebo mengalami penurunan sebesar -1.74±1.79 μm dari 97.14±17.19 μm di awal penelitian
menjadi 95.40±18.56 μm setelah 8 minggu, perubahan yang terjadi bermakna secara statistik (p< 0.001). Rerata MD lapang pandang kelompok Mirtogenol mengalami peningkatan 0.542±1.93 dB setelah 8 minggu sedangkan rerata MD lapang pandang kelompok plasebo mengalami penurunan sebesar -0.083±1.36 dB setelah 8 minggu. Namun perubahan rerata MD lapang pandang kedua kelompok
tidak bermakna secara statistik (p>0.05). Selama penelitian tidak didapatkan adanya efek samping.
Kesimpulan: Mirtogenol dapat mempertahankan ketebalan lapisan serabut saraf retina, dan MD lapang pandang pada pemberian Mirtogenol cenderung meningkat.
ABSTRACTObjective: To evaluate the effect of Mirtogenol towards the changes in retinal nerve fiber layer (RNFL) thickness and visual field in patients with primary open angle glaucoma (POAG) with controlled IOP.
Methods: This is a prospective, double blind, randomized study. Forty one POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after the treatment. Patients were asked for any side effects during the treatment period.
Results: The average RNFL thickness in the Mirtogenol group decreased 0.70±1.63 μm from 87.29±19.39 μm before the treatment to 86.58±19.43 μm after 8 weeks of treatment, however the change was not significant (p=0.121). The average RNFL thickness in the placebo group decreased -1.74±1.79 μm from 97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of treatment, the change was statistically significant (p< 0.001). The average MD of visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of
treatment while the MD of visual field in the placebo group decreased 0.083 ± 1.36 dB after 8 weeks of treatment. Hoewever the changes in MD of visual field was not significant (p>0.05). No side effect was found throughout the study.
Conclusions: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields.;Objective: To evaluate the effect of Mirtogenol towards the changes in retinal
nerve fiber layer (RNFL) thickness and visual field in patients with primary open
angle glaucoma (POAG) with controlled IOP.
Methods: This is a prospective, double blind, randomized study. Forty one
POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either
Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual
fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after
the treatment. Patients were asked for any side effects during the treatment period.
Results: The average RNFL thickness in the Mirtogenol group decreased 0.70±1.63
μm
from
87.29±19.39
μm
before
the
treatment
to
86.58±19.43
μm
after
8
weeks of treatment, however the change was not significant (p=0.121). The
average RNFL thickness in the placebo group decreased -1.74±1.79 μm from
97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of
treatment, the change was statistically significant (p< 0.001). The average MD of
visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of
treatment while the MD of visual field in the placebo group decreased 0.083±1.36
dB
after
8
weeks
of
treatment.
Hoewever
the
changes
in
MD
of
visual
field
was
not
significant
(p>0.05).
No
side effect
was
found throughout
the
study.
Conclusions: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields., Objective: To evaluate the effect of Mirtogenol towards the changes in retinal
nerve fiber layer (RNFL) thickness and visual field in patients with primary open
angle glaucoma (POAG) with controlled IOP.
Methods: This is a prospective, double blind, randomized study. Forty one
POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either
Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual
fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after
the treatment. Patients were asked for any side effects during the treatment period.
Results: The average RNFL thickness in the Mirtogenol group decreased 0.70±1.63
μm
from
87.29±19.39
μm
before
the
treatment
to
86.58±19.43
μm
after
8
weeks of treatment, however the change was not significant (p=0.121). The
average RNFL thickness in the placebo group decreased -1.74±1.79 μm from
97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of
treatment, the change was statistically significant (p< 0.001). The average MD of
visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of
treatment while the MD of visual field in the placebo group decreased 0.083±1.36
dB
after
8
weeks
of
treatment.
Hoewever
the
changes
in
MD
of
visual
field
was
not
significant
(p>0.05).
No
side effect
was
found throughout
the
study.
Conclusions: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields.]
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