[ABSTRAK
Latar Belakang: Kemoterapi pada kanker kolorektal (KKR) telah mengalamiperkembangan yang amat pesat dalam dua dasawarsa ini. Berikut akanditampilkan deskripsi data kemoterapi pada keganasan kolorektal di RSCMperiode Januari 2010-Agustus 2012. Metode: Data didapat dari registrasi rekammedik Januari 2010-Agustus 2012 secara retrospektif, diolah dengan programSPSS 11. 5, kemudian dievaluasi. Hasil: Menggambarkan pasien KKR didominasijenis kelamin laki-laki 66,7 %. Usia terbanyak pada kategori usia 60-69 tahun.Ada perbedaan antara kejadian tumor rektum pada pria dan wanita (perbandingan2:1). Histopatologi terbanyak adalah adenokarsinoma 94,9 %. KKR terletakpaling sering di rektum 48,7 %. Pasien KKR lebih banyak ditemukan padastadium III (35,9%), K-Ras terbanyak ditemukan adalah jenis wild-type. Pada 34kasus (87,2%) KKR dengan nilai CEA di atas normal. Pemberian kemoterapi padakanker kolorektal tidak sesuai dengan panduan NCCN 2012 dan PanduanNasional Pengelolaan KKR 2004. Efek samping terbanyak adalah vomitus,anorexia dan dispepsia, sedangkan efek samping lain tersebar merata. Sebanyak19 pasien (48,7%) tidak menyelesaikan kemoterapi, 11 pasien (28,2%)menyelesaikan kemoterapi dan 9 orang (23,1%) belum menyelesaikankemoterapi. Alasan terbanyak tidak menyelesaikan kemoterapi adalah karena efeksamping. Penggunaan capecitabine seluruhnya mengeluhkan hands and footsyndrome, sebanyak 7 orang (70%) tingkat 3 dan 3 (30%) orang tingkat 2.Kesimpulan: Data pasien-pasien KKR di Divisi Bedah Digestif RSCM-FKUI periode Januari 2010-Agustus 2012 menggambarkan bahwa penggunaan regimen kemoterapi belum sepenuhnya mengikuti pedoman kemoterapi pada kanker kolorektal.ABSTRACT Background: Chemotherapy in colorectal cancer (CRC) is growing rapidly todays.

We describe the characteristic data about chemotherapy for CRC in Cipto

Mangunkusumo Hospital January 2010-August 2012. Methods: Data was

collected from the medical record center retrospectively from January 2010August

2012, proceesed by SPSS 11. 5 software, then evaluated. Results: Data

described the characteristic of gender is dominated by male (66.7 %) with ratio

2:1 between male and female. Higher incidence is in category 60-69 years old.

The most histological found is adenocarcinoma type (94.9%). The most location

found is in rectum (48.7%). Patient with CRC often found in stadium III (35.9%).

The most K-Ras result found is wild-type. In 34 cases (87.2%) of CRC with

higher CEA values. Data for patients who undergone chemotherapiutic are

inappropriate with standard protocol from NCCN 2012 and Panduan Nasional

Pengelolaan KKR 2004. All patients complained vomitus, anorexia and

dyspepsia, in spite other sides effect are spread evenly. About 19 patients (48.7%)

did not finish chemotherapy, 11 patients (28.2%) finished chemotherapy, and 9

patients (23.1%) are in chemotherapiutic now. Those reasons are patient

waywardness because side effect, medical record error, inappropriate patients

directing for follow up and unavailable regiment. All patients whom use

capecitabine complained hands and foot syndrome with 7 patients (70%) grade 3

and 3 patients (30%) grade 2. Conclusions: From the data we presented, it

describe that data for patients who undergone chemotherapiutic are inappropriate with standard protocol for chemotherapy for CRC., Background: Chemotherapy in colorectal cancer (CRC) is growing rapidly todays.

We describe the characteristic data about chemotherapy for CRC in Cipto

Mangunkusumo Hospital January 2010-August 2012. Methods: Data was

collected from the medical record center retrospectively from January 2010August

2012, proceesed by SPSS 11. 5 software, then evaluated. Results: Data

described the characteristic of gender is dominated by male (66.7 %) with ratio

2:1 between male and female. Higher incidence is in category 60-69 years old.

The most histological found is adenocarcinoma type (94.9%). The most location

found is in rectum (48.7%). Patient with CRC often found in stadium III (35.9%).

The most K-Ras result found is wild-type. In 34 cases (87.2%) of CRC with

higher CEA values. Data for patients who undergone chemotherapiutic are

inappropriate with standard protocol from NCCN 2012 and Panduan Nasional

Pengelolaan KKR 2004. All patients complained vomitus, anorexia and

dyspepsia, in spite other sides effect are spread evenly. About 19 patients (48.7%)

did not finish chemotherapy, 11 patients (28.2%) finished chemotherapy, and 9

patients (23.1%) are in chemotherapiutic now. Those reasons are patient

waywardness because side effect, medical record error, inappropriate patients

directing for follow up and unavailable regiment. All patients whom use

capecitabine complained hands and foot syndrome with 7 patients (70%) grade 3

and 3 patients (30%) grade 2. Conclusions: From the data we presented, it

describe that data for patients who undergone chemotherapiutic are inappropriate with standard protocol for chemotherapy for CRC.]