This book presents a comprehensive review on latest research and development trends for design optimization of mechanical elements and devices. Using examples of various mechanical elements and devices, the possibilities for design optimization with advanced optimization techniques are demonstrated. Basic and advanced concepts of traditional and advanced optimization techniques are presented, along with real case studies, results of applications of the proposed techniques, and the best optimization strategies to achieve best performance are highlighted. Furthermore, a novel advanced optimization method named teaching-learning-based optimization (TLBO) is presented in this book and this method shows better performance with less computational effort for the large scale problems.