Gastrointestinal manifestations are common is systemic lupus erythematosus (SLE). Although the relationship between SLE with ulcerative colitis (UC) rarely obtained, SLE patients with gastrointestinal manifestations should preferably be evaluated for the possibility of an inflammatory bowel disease (IBD). UC prognosis associated with SLE is usually good, whereas by proper diagnosis and management, the clinical output and a good life expectancy of patients will be obtained. A young female, 17 years old, who had previously been diagnoses with SLE for 5 years, come with complaints of abdominal pain and chronic diarrhea. From the result of colonoscopy and biopsy of the intestinal mucosa was noted that in accordance with UC. After receiving treatment for 6 days, she no longer obtained compalints of abdominal pain and diarrhea.