Kejadian systemic inflammatory response syndrome pada anak pasca bedah jantung terbuka dan hubungannya dengan durasi penggunaan mesin pintas jantung paru = Incidence of systemic inflammatory response syndrome on children undergoing open heart surgery and its association with the duration of cardiopulmonary bypass

Nico Iswanto Pantoro, author

Kejadian systemic inflammatory response syndrome pada anak pasca bedah jantung terbuka dan hubungannya dengan durasi penggunaan mesin pintas jantung paru = Incidence of systemic inflammatory response syndrome on children undergoing open heart surgery and its association with the duration of cardiopulmonary bypass

Nico Iswanto Pantoro; Aldy Heriwardito, supervisor; Aldy Heriwardito, examiner; Luluk Yunaini, examiner ([Fakultas Kedokteran Universitas Indonesia;Fakultas Kedokteran Universitas Indonesia, Fakultas Kedokteran Universitas Indonesia], 2015)

Abstrak

[Kejadian Systemic Inflammatory Response Syndrome (SIRS) pasca bedah jantung terbuka masih merupakan salah satu komplikasi yang banyak ditemukan. Salah satu faktor risikonya adalah durasi pintas jantung. Studi kohort retrospektif dilakukan terhadap 187 pasien bedah jantung terbuka di RSUPN Cipto Mangunkusumo tahun 2014-2015. Subjek dibedakan menjadi 2 kelompok berdasarkan durasi pintas jantung (durasi >60 menit dan ≤60 menit). Sebanyak 107 (57,2%) pasien mengalami SIRS dalam 24 jam pasca operasi. Kejadian SIRS ditemukan pada 75 (65,8%) pasien dari kelompok durasi >60 menit dan 32 (43,8%) pasien dari

kelompok durasi ≤60 menit. Melalui analisis multivariat regresi logistik, didapatkan hubungan bermakna (p<0,05) antara durasi CPB dan SIRS dengan OR2,04 (IK95% 1,05-3,93). Durasi CPB merupakan faktor risiko independen dari kejadian SIRS pasca bedah jantung terbuka.

Sytemic inflammatory Response Syndrome (SIRS) is a major complication foundat patient following open heart surgery. One of the risk factors is the duration of the

cardiopulmonary bypass. A historical cohort study had been done on 187 postcardiac surgery patients in RSUPN Cipto Mangunkusumo. The subjects were divided into 2 separate groups based on the duration of cardiopulmonary bypass (duration >60 minutes and ≤60 minutes). There were 107 (57.2%) patients having SIRS within 24 hours following the surgery. SIRS was found on 75 (65.8%)

patients from group with duration >60 minutes and 32 (43.8%) patients from group with duration ≤60 minutes. Through logistic regression multivariate analysis, there

was a significant difference (p<0.05) with OR 2.04 (CI95% 1.05-3.93) between two groups. Therefore, duration of cardiopulmonary bypass was an independent risk factor of post open heart surgery SIRS.;Sytemic Inflammatory Response Syndrome (SIRS) is a major complication found

at patient following open heart surgery. One of the risk factors is the duration of the

cardiopulmonary bypass. A historical cohort study had been done on 187 postcardiac

surgery patients in RSUPN Cipto Mangunkusumo. The subjects were

divided into 2 separate groups based on the duration of cardiopulmonary bypass

(duration >60 minutes and ≤60 minutes). There were 107 (57.2%) patients having

SIRS within 24 hours following the surgery. SIRS was found on 75 (65.8%)

patients from group with duration >60 minutes and 32 (43.8%) patients from group

with duration ≤60 minutes. Through logistic regression multivariate analysis, there

was a significant difference (p<0.05) with OR 2.04 (CI95% 1.05-3.93) between two

groups. Therefore, duration of cardiopulmonary bypass was an independent risk

factor of post open heart surgery SIRS;Sytemic Inflammatory Response Syndrome (SIRS) is a major complication found