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Perbandingan reaksi obat yang tidak dikehendaki dari kontrasepsi oral kombinasi antara levonorgestrel dan desogestrel di Kecamatan Sukmajaya Kota Depok = Comparison of adverse drug reactions between combined oral contraceptive contain levonorgestrel and desogestrel in Sukmajaya Districts Depok City

Kartika Citra Dewi Permata Sari; Retnosari Andrajati, supervisor; Sudibyo Supardi, supervisor; Effionora Anwar, co-promotor; Ratu Ayu Dewi Sartika, examiner; Budiharto, examiner ([Publisher not identified] , 2015)
 Abstrak
[ABSTRAK
Kontrasepsi oral menempati peringkat kedua metode kontrasepsi yang paling
banyak digunakan di Indonesia, namun tingkat putus obat akibat reaksi obat yang
tidak dikehendaki (ROTD) cukup tinggi (13,2%). Hanya sebagian kecil akseptor
(23,9%) yang diberikan informasi tentang hal yang dapat dilakukan jika mengalami
ROTD seperti pilihan kontrasepsi oral dengan progestin generasi terbaru yang
memiliki efek samping lebih rendah. Tujuan penelitian ini adalah membandingkan
ROTD dari pil kontrasepsi kombinasi yang berisi levonorgestrel (generasi kedua)
dengan desogestrel (generasi ketiga). Metode penelitian ini adalah potong lintang
komparatif dengan sampel yang diperoleh secara acak dari enam kelurahan di
kecamatan Sukmajaya Depok pada rentang waktu Agustus ? November 2015.
Pengambilan data dilakukan menggunakan metode wawancara. Sampel penelitian
adalah 60 akseptor kelompok levonorgestrel dan 40 akseptor kelompok desogestrel.
Keluhan ROTD meliputi perdarahan di luar menstruasi (16,7%;5%), sakit kepala
(16,7% ; 5%), mual/muntah (25% ; 0), nyeri payudara (13,3% ; 0), gangguan terkait
hubungan seksual (23,3% ; 7,5%), penambahan berat badan (35% ; 22,5%), jerawat
(3,3% ; 7,5%) dan chloasma (28,3% ; 5%). Proporsi kejadian tersebut secara
signifikan lebih tinggi pada kelompok levonorgestrel pada gangguan hubungan
seksual (OR 3,75, 95% CI : 1,003 ? 14,050, p = 0,039) dan chloasma (OR 7,51, 95%
CI : 1,629 ? 34,647, p = 0,004).

ABSTRACT
Oral contraceptive was second contraception method most widely used in Indonesia,
but had high percentage rate (13,2%) of withdrawal due to adverse drug reactions
(ADR). Only small portion users (23,9%) who had been provided information about
other oral contraceptive with the newer progestin generation as alternative option
to minimize ADR. This study was conducted to compare prevalence of ADR
between combined oral contraceptives contain levonorgestrel (second generation)
and desogestrel (third generation) which expected to have less side effects. Study
was done as cross sectional comparative design with random sampling from users
in six villages in Sukmajaya district, Depok City. Data were collected by interview.
Samples consists of 60 users of levonorgestrel and 40 users of desogestrel. ADR
complaints include intermenstrual bleeding (16.7%; 5%), headache (16.7%; 5%),
nausea/vomiting (25%; 0), breast tenderness (13.3%; 0), impaired sexual
intercourse (23.3%; 7.5%), weight gain (35%; 22.5%), acne (3.3%; 7.5%) and
chloasma (28.3%; 5%). The proportion of these events was significantly higher in
the group of levonorgestrel for impaired sexual intercourse (OR 3.75, 95% CI:
1.003 to 14.050, p = 0.039) and chloasma (OR 7.51, 95% CI: 1.629 to 34.647, p =
0.004).;Oral contraceptive was second contraception method most widely used in Indonesia,
but had high percentage rate (13,2%) of withdrawal due to adverse drug reactions
(ADR). Only small portion users (23,9%) who had been provided information about
other oral contraceptive with the newer progestin generation as alternative option
to minimize ADR. This study was conducted to compare prevalence of ADR
between combined oral contraceptives contain levonorgestrel (second generation)
and desogestrel (third generation) which expected to have less side effects. Study
was done as cross sectional comparative design with random sampling from users
in six villages in Sukmajaya district, Depok City. Data were collected by interview.
Samples consists of 60 users of levonorgestrel and 40 users of desogestrel. ADR
complaints include intermenstrual bleeding (16.7%; 5%), headache (16.7%; 5%),
nausea/vomiting (25%; 0), breast tenderness (13.3%; 0), impaired sexual
intercourse (23.3%; 7.5%), weight gain (35%; 22.5%), acne (3.3%; 7.5%) and
chloasma (28.3%; 5%). The proportion of these events was significantly higher in
the group of levonorgestrel for impaired sexual intercourse (OR 3.75, 95% CI:
1.003 to 14.050, p = 0.039) and chloasma (OR 7.51, 95% CI: 1.629 to 34.647, p =
0.004)., Oral contraceptive was second contraception method most widely used in Indonesia,
but had high percentage rate (13,2%) of withdrawal due to adverse drug reactions
(ADR). Only small portion users (23,9%) who had been provided information about
other oral contraceptive with the newer progestin generation as alternative option
to minimize ADR. This study was conducted to compare prevalence of ADR
between combined oral contraceptives contain levonorgestrel (second generation)
and desogestrel (third generation) which expected to have less side effects. Study
was done as cross sectional comparative design with random sampling from users
in six villages in Sukmajaya district, Depok City. Data were collected by interview.
Samples consists of 60 users of levonorgestrel and 40 users of desogestrel. ADR
complaints include intermenstrual bleeding (16.7%; 5%), headache (16.7%; 5%),
nausea/vomiting (25%; 0), breast tenderness (13.3%; 0), impaired sexual
intercourse (23.3%; 7.5%), weight gain (35%; 22.5%), acne (3.3%; 7.5%) and
chloasma (28.3%; 5%). The proportion of these events was significantly higher in
the group of levonorgestrel for impaired sexual intercourse (OR 3.75, 95% CI:
1.003 to 14.050, p = 0.039) and chloasma (OR 7.51, 95% CI: 1.629 to 34.647, p =
0.004).]
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 Metadata
No. Panggil : T45305
Nama orang :
Nama orang tambahan :
Nama badan tambahan :
Subjek :
Penerbitan : [Place of publication not identified]: [Publisher not identified], 2015
Program Studi :
Sumber Pengatalogan : LibUI ind rda
Tipe Konten : text
Tipe Media : unmediated ; computer
Tipe Carrier : volume ; online resource
Deskripsi Fisik : xv, 143 pages : illustration ; 30 cm + appendix
Catatan Bibliografi : pages 77-82
Lembaga Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
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No. Panggil No. Barkod Ketersediaan
T45305 15-17-645954567 TERSEDIA
Ulasan:
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