[ABSTRAK
Kontrasepsi oral menempati peringkat kedua metode kontrasepsi yang palingbanyak digunakan di Indonesia, namun tingkat putus obat akibat reaksi obat yangtidak dikehendaki (ROTD) cukup tinggi (13,2%). Hanya sebagian kecil akseptor(23,9%) yang diberikan informasi tentang hal yang dapat dilakukan jika mengalamiROTD seperti pilihan kontrasepsi oral dengan progestin generasi terbaru yangmemiliki efek samping lebih rendah. Tujuan penelitian ini adalah membandingkanROTD dari pil kontrasepsi kombinasi yang berisi levonorgestrel (generasi kedua)dengan desogestrel (generasi ketiga). Metode penelitian ini adalah potong lintangkomparatif dengan sampel yang diperoleh secara acak dari enam kelurahan dikecamatan Sukmajaya Depok pada rentang waktu Agustus ? November 2015.Pengambilan data dilakukan menggunakan metode wawancara. Sampel penelitianadalah 60 akseptor kelompok levonorgestrel dan 40 akseptor kelompok desogestrel.Keluhan ROTD meliputi perdarahan di luar menstruasi (16,7%;5%), sakit kepala(16,7% ; 5%), mual/muntah (25% ; 0), nyeri payudara (13,3% ; 0), gangguan terkaithubungan seksual (23,3% ; 7,5%), penambahan berat badan (35% ; 22,5%), jerawat(3,3% ; 7,5%) dan chloasma (28,3% ; 5%). Proporsi kejadian tersebut secarasignifikan lebih tinggi pada kelompok levonorgestrel pada gangguan hubunganseksual (OR 3,75, 95% CI : 1,003 ? 14,050, p = 0,039) dan chloasma (OR 7,51, 95%CI : 1,629 ? 34,647, p = 0,004).

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ABSTRACT

Oral contraceptive was second contraception method most widely used in Indonesia,

but had high percentage rate (13,2%) of withdrawal due to adverse drug reactions

(ADR). Only small portion users (23,9%) who had been provided information about

other oral contraceptive with the newer progestin generation as alternative option

to minimize ADR. This study was conducted to compare prevalence of ADR

between combined oral contraceptives contain levonorgestrel (second generation)

and desogestrel (third generation) which expected to have less side effects. Study

was done as cross sectional comparative design with random sampling from users

in six villages in Sukmajaya district, Depok City. Data were collected by interview.

Samples consists of 60 users of levonorgestrel and 40 users of desogestrel. ADR

complaints include intermenstrual bleeding (16.7%; 5%), headache (16.7%; 5%),

nausea/vomiting (25%; 0), breast tenderness (13.3%; 0), impaired sexual

intercourse (23.3%; 7.5%), weight gain (35%; 22.5%), acne (3.3%; 7.5%) and

chloasma (28.3%; 5%). The proportion of these events was significantly higher in

the group of levonorgestrel for impaired sexual intercourse (OR 3.75, 95% CI:

1.003 to 14.050, p = 0.039) and chloasma (OR 7.51, 95% CI: 1.629 to 34.647, p =

0.004).;Oral contraceptive was second contraception method most widely used in Indonesia,

but had high percentage rate (13,2%) of withdrawal due to adverse drug reactions

(ADR). Only small portion users (23,9%) who had been provided information about

other oral contraceptive with the newer progestin generation as alternative option

to minimize ADR. This study was conducted to compare prevalence of ADR

between combined oral contraceptives contain levonorgestrel (second generation)

and desogestrel (third generation) which expected to have less side effects. Study

was done as cross sectional comparative design with random sampling from users

in six villages in Sukmajaya district, Depok City. Data were collected by interview.

Samples consists of 60 users of levonorgestrel and 40 users of desogestrel. ADR

complaints include intermenstrual bleeding (16.7%; 5%), headache (16.7%; 5%),

nausea/vomiting (25%; 0), breast tenderness (13.3%; 0), impaired sexual

intercourse (23.3%; 7.5%), weight gain (35%; 22.5%), acne (3.3%; 7.5%) and

chloasma (28.3%; 5%). The proportion of these events was significantly higher in

the group of levonorgestrel for impaired sexual intercourse (OR 3.75, 95% CI:

1.003 to 14.050, p = 0.039) and chloasma (OR 7.51, 95% CI: 1.629 to 34.647, p =

0.004)., Oral contraceptive was second contraception method most widely used in Indonesia,

but had high percentage rate (13,2%) of withdrawal due to adverse drug reactions

(ADR). Only small portion users (23,9%) who had been provided information about

other oral contraceptive with the newer progestin generation as alternative option

to minimize ADR. This study was conducted to compare prevalence of ADR

between combined oral contraceptives contain levonorgestrel (second generation)

and desogestrel (third generation) which expected to have less side effects. Study

was done as cross sectional comparative design with random sampling from users

in six villages in Sukmajaya district, Depok City. Data were collected by interview.

Samples consists of 60 users of levonorgestrel and 40 users of desogestrel. ADR

complaints include intermenstrual bleeding (16.7%; 5%), headache (16.7%; 5%),

nausea/vomiting (25%; 0), breast tenderness (13.3%; 0), impaired sexual

intercourse (23.3%; 7.5%), weight gain (35%; 22.5%), acne (3.3%; 7.5%) and

chloasma (28.3%; 5%). The proportion of these events was significantly higher in

the group of levonorgestrel for impaired sexual intercourse (OR 3.75, 95% CI:

1.003 to 14.050, p = 0.039) and chloasma (OR 7.51, 95% CI: 1.629 to 34.647, p =

0.004).]