ABSTRAK Latar Belakang. Kemajuan dalam penanganan bayi prematur menyebabkan
angka kesintasan meningkat. Akibatnya, angka kesakitan bayi prematur juga
meningkat, salah satunya adalah osteopenia of prematurity (OOP). Pemeriksaan
kadar kalsium, fosfat, dan fosfatase alkali serum saat usia kronologis 4 minggu
digunakan sebagai indikator awal sebelum osteopenia tampak secara klinis.
Diagnosis sedini mungkin dan pengendalian faktor risiko perlu dilakukan
sehingga komplikasi dapat dicegah.
Tujuan. Mengetahui prevalens dan faktor risiko terjadinya OOP.
Desain Penelitian. Penelitian dengan desain potong lintang ini dilaksanakan
pada bayi prematur dengan usia gestasi ≤32 minggu di Divisi Perinatalogi RS Dr.
Cipto Mangunkusumo. Subyek diperiksa kadar kalsium serum, fosfat inorganik
serum, dan fosfatase alkali serum. Pada subyek dilakukan pencatatan faktor risiko
OOP untuk menilai hubungan antar variabel dan dilakukan analisis bivariat
dengan uji chi square.
Hasil Penelitian. Terdapat 80 subyek yang memenuhi kriteria penelitian.
Delapan dari 80 subyek (10%) ditemukan menderita OOP. Faktor risiko yang
dianalisis dalam penelitian ini ditemukan tidak memiliki hubungan bermakna
dengan kejadian OOP, yakni lama penggunaan nutrisi parenteral total (p=0,457),
lama penggunaan metilsantin (p=1,000), berat lahir (p=0,459), preeklampsia
berat pada ibu (p=0,344), korioamnionitis pada ibu (p=0,261), dan pemberian
nutrisi enteral (p=0,797).
Simpulan. Prevalens OOP di RS Dr. Cipto Mangunkusumo adalah 10%. Faktor
lama penggunaan nutrisi parenteral total, penggunaan metilsantin, berat lahir,
preeklampsia berat pada ibu, korioamnionitis, dan pemberian nutrisi enteral tidak memiliki hubungan bermakna dengan kejadian OOP.
ABSTRACT Background. Advances in management of premature infants had increased the
survival rate of these infants. However there is also increase of morbidity such as
osteopenia of prematurity (OOP). Laboratory examination of serum calcium,
phosphate, and alkaline phosphatase at the chronological age of 4 weeks is used
as early indicator before osteopenia become clinically appearant. Early diagnosis
and risk control are needed to prevent complication.
Objective. To evaluate the prevalence and risk factors of OOP.
Methods. A cross sectional study was done in premature infants <32 weeks of
gestational age in Perinatalogy Division of Cipto Mangunkusumo Hospital.
Laboratory examination of serum calcium, phosphate, and alkaline
phosphatasewere conducted toward these subjects. Risk factors of OOP were also
evaluated. Bivariat analysis was analysed by chi square test.
Results. There are 80 subjects who meet the study criteria. Eight of 80 subjects
(10%) was diagnosed as OOP. No risk factors have significant relationship with
OOP incidence, which include duration of total parenteral nutrition (p=0,457),
duration of methylxanthine usage (p=1,000), birth weight (p=0,459), severe
preecalampsia in the mother (p=0,344), chorioamnionitis in the mother
(p=0,261), and enteral nutrition (p=0,797).
Conclusion. Prevalence of OOP in Cipto Mangunkusumo Hospital is 10%. There
are no significant relationship between OOP incidence and duration of total
parenteral nutrition, methylxanthine usage, birth weight, severe preeclampsia in the mother, chorioamnionitis, and enteral nutrition.
;Background. Advances in management of premature infants had increased the
survival rate of these infants. However there is also increase of morbidity such as
osteopenia of prematurity (OOP). Laboratory examination of serum calcium,
phosphate, and alkaline phosphatase at the chronological age of 4 weeks is used
as early indicator before osteopenia become clinically appearant. Early diagnosis
and risk control are needed to prevent complication.
Objective. To evaluate the prevalence and risk factors of OOP.
Methods. A cross sectional study was done in premature infants <32 weeks of
gestational age in Perinatalogy Division of Cipto Mangunkusumo Hospital.
Laboratory examination of serum calcium, phosphate, and alkaline
phosphatasewere conducted toward these subjects. Risk factors of OOP were also
evaluated. Bivariat analysis was analysed by chi square test.
Results. There are 80 subjects who meet the study criteria. Eight of 80 subjects
(10%) was diagnosed as OOP. No risk factors have significant relationship with
OOP incidence, which include duration of total parenteral nutrition (p=0,457),
duration of methylxanthine usage (p=1,000), birth weight (p=0,459), severe
preecalampsia in the mother (p=0,344), chorioamnionitis in the mother
(p=0,261), and enteral nutrition (p=0,797).
Conclusion. Prevalence of OOP in Cipto Mangunkusumo Hospital is 10%. There
are no significant relationship between OOP incidence and duration of total
parenteral nutrition, methylxanthine usage, birth weight, severe preeclampsia in the mother, chorioamnionitis, and enteral nutrition.
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