ABSTRAK Tesis ini bertujuan menilai perbandingan efektivitas injeksi intravitreal
vorikonazol 100 µg/0.1 mL dengan amfoterisin B 5 µg/0.1 mL pada endoftalmitis
akibat Aspergillus flavus di hewan coba kelinci. Uji eksperimental tersamar acak
dilakukan pada 15 kelinci albino New Zealand white yang terbagi menjadi tiga
kelompok, yaitu kelompok vorikonazol, amfoterisin B, dan kontrol. Parameter
yang dinilai adalah perubahan klinis, pemeriksaan mikologi, dan perubahan
histopatologi jaringan. Perubahan skor klinis di akhir evaluasi tidak berbeda
bermakna antara kelompok vorikonazol dengan amfoterisin B, namun respons
klinis cenderung lebih baik pada kelompok vorikonazol. Jumlah koloni jamur
terkecil dan berbeda bermakna didapatkan pada kelompok amfoterisin B. Tidak
didapatkan perbedaan bermakna pada rerata nilai histopatologi jaringan kedua
kelompok, namun derajat inflamasi cenderung lebih ringan pada kelompok vorikonazol.
ABSTRACT The purpose of this study was to compare the efficacies of intravitreal 100 µg voriconazole and 5 µg amphotericin B treatment against Aspergillus flavus in an
exogenous endophthalmitis model in rabbit eyes. A randomized, controlledexperimental
study was conducted on 15 albino New Zealand white rabbits, which latter allocated into three different
treatment group of voriconazole, amphotericin B, and control. Clinical grading were performed at multiple times, while mycology analysis and histopathological examination were performed at 10 days
after treatment. No significant change in clinical grading was found between the
treatment group, but voriconazole group showed better response tendency. The smallest number of fungal colony forming unit was found significantly in the
amphotericin B group. No significant difference was found, however, between the mean histopathological score of the two treatment groups, but the tendency of a lower inflammation score was shown in voriconazole group. ;The purpose of this study was to compare the efficacies of intravitreal 100 µg
voriconazole and 5 µg amphotericin B treatment against Aspergillus flavus in an
exogenous endophthalmitis model in rabbit eyes. A randomized, controlledexperimental
study
was
conducted
on
15
albino
New
Zealand
white
rabbits,
which
latter
allocated
into
three
different
treatment
group
of
voriconazole,
amphotericin
B,
and control. Clinical grading were performed at multiple times, while
mycology analysis and histopathological examination were performed at 10 days
after treatment. No significant change in clinical grading was found between the
treatment group, but voriconazole group showed better response tendency. The
smallest number of fungal colony forming unit was found significantly in the
amphotericin B group. No significant difference was found, however, between the
mean histopathological score of the two treatment groups, but the tendency of a lower inflammation score was shown in voriconazole group. ;The purpose of this study was to compare the efficacies of intravitreal 100 µg
voriconazole and 5 µg amphotericin B treatment against Aspergillus flavus in an
exogenous endophthalmitis model in rabbit eyes. A randomized, controlledexperimental
study
was
conducted
on
15
albino
New
Zealand
white
rabbits,
which
latter
allocated
into
three
different
treatment
group
of
voriconazole,
amphotericin
B,
and control. Clinical grading were performed at multiple times, while
mycology analysis and histopathological examination were performed at 10 days
after treatment. No significant change in clinical grading was found between the
treatment group, but voriconazole group showed better response tendency. The
smallest number of fungal colony forming unit was found significantly in the
amphotericin B group. No significant difference was found, however, between the
mean histopathological score of the two treatment groups, but the tendency of a lower inflammation score was shown in voriconazole group. ;The purpose of this study was to compare the efficacies of intravitreal 100 µg
voriconazole and 5 µg amphotericin B treatment against Aspergillus flavus in an
exogenous endophthalmitis model in rabbit eyes. A randomized, controlledexperimental
study
was
conducted
on
15
albino
New
Zealand
white
rabbits,
which
latter
allocated
into
three
different
treatment
group
of
voriconazole,
amphotericin
B,
and control. Clinical grading were performed at multiple times, while
mycology analysis and histopathological examination were performed at 10 days
after treatment. No significant change in clinical grading was found between the
treatment group, but voriconazole group showed better response tendency. The
smallest number of fungal colony forming unit was found significantly in the
amphotericin B group. No significant difference was found, however, between the
mean histopathological score of the two treatment groups, but the tendency of a lower inflammation score was shown in voriconazole group.
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