ABSTRAK
Latar belakang Glaukoma masih merupakan salah satu penyebab kebutaan terbesar di dunia. Belakangan ini, ketebalan RFNL dan GCIPL diketahui memilikihubungan terhadap perubahan struktural yang disebabkan oleh glaukoma. Tujuan untuk mengkaji kemampuan diagnostik dari pengukuran ketebalan RFNLdan GCIPL dalam mendeteksi glaukoma pada tahap awal.Metode Enam puluh empat mata dengan sudut bilik mata sempit (32 glaukoma,32 non-glaukoma) dari 48 pasien menjalani pengukuran menggunakan CirrusOCT dengan protokol 3,4 mm pemindaian cepat RFNL peripapilar. Pengukurandilakukan pada sisi superior, inferior, nasal, temporal dari GCIPL dan RFNL,begitu juga dengan GCIPL superotemporal, superonasal, inferotemporal,inferonasal, dan minimal. Hasil Semua parameter yang diuji pada studi ini menunjukkan angka yang lebihrendah pada kelompok PACG dibandingkan kelompok PAC. Rerata ketebalanRFNL dan ketebalan GCIPL inferotemporal masing-masing memiliki nilaispesifitias dan sensitifitas yang paling baik. Parameter dengan determinan terbaikadalah ketebalan GCIPL inferotemporal dengan sensitifitas dan spesifitas masingmasing75%dan75%.KesimpulanKetebalan GCIPL dan RFNL peripapil memiliki potensi besarsebagai parameter diagnostik seperti skrining dan evaluasi respon terapi.ABSTRACT
Background Glaucoma remains one of the biggest causes of blindnessworldwide. Recently, RFNL and GCIPL thickness were shown to be correlatedwith early structural changes caused by glaucoma. Objective to evaluate the diagnostic performance of RFNL and GCIPL thicknessmeasurement in detecting early glaucoma Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)of48patients underwent peripapillar scanning using Cirrus OCTusing 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurementincludes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well assuperotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL. Result All parameters studied were significantly thinner in PACG groupcompared to PAC group. Mean RFNL thickness and inferotemporal GCIPL hasthe highest specificity and sensitivity, respectively, in detecting glaucoma.Parameter with the best determinant is inferotemporal GCIPL thickness withsensitivity and specificity, 75% and 71.9%, respectively. Conclusion Peripapillary RFNL and GCIPL could be a potential diagnosticparameter in detecting early glaucoma and monitoring therapy response inglaucoma patients. ;Background Glaucoma remains one of the biggest causes of blindnessworldwide. Recently, RFNL and GCIPL thickness were shown to be correlatedwith early structural changes caused by glaucoma. Objective to evaluate the diagnostic performance of RFNL and GCIPL thicknessmeasurement in detecting early glaucoma Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)of48patients underwent peripapillar scanning using Cirrus OCTusing 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurementincludes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well assuperotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL. Result All parameters studied were significantly thinner in PACG groupcompared to PAC group. Mean RFNL thickness and inferotemporal GCIPL hasthe highest specificity and sensitivity, respectively, in detecting glaucoma.Parameter with the best determinant is inferotemporal GCIPL thickness withsensitivity and specificity, 75% and 71.9%, respectively. Conclusion Peripapillary RFNL and GCIPL could be a potential diagnosticparameter in detecting early glaucoma and monitoring therapy response inglaucoma patients. ;Background Glaucoma remains one of the biggest causes of blindnessworldwide. Recently, RFNL and GCIPL thickness were shown to be correlatedwith early structural changes caused by glaucoma. Objective to evaluate the diagnostic performance of RFNL and GCIPL thicknessmeasurement in detecting early glaucoma Method Sixty-four eyes with primary angle closure (32 glaucomatous, 32 nonglaucomatous)of48patients underwent peripapillar scanning using Cirrus OCTusing 3,4 mm protocol fast RNFL peripapillary thickness scan. The measurementincludes superior, inferior, nasal, temporal, mean GCIPL and RFNL, as well assuperotemporal, superonasal, inferotemporal, inferonasal, minimal GCIPL. Result All parameters studied were significantly thinner in PACG groupcompared to PAC group. Mean RFNL thickness and inferotemporal GCIPL hasthe highest specificity and sensitivity, respectively, in detecting glaucoma.Parameter with the best determinant is inferotemporal GCIPL thickness withsensitivity and specificity, 75% and 71.9%, respectively. Conclusion Peripapillary RFNL and GCIPL could be a potential diagnosticparameter in detecting early glaucoma and monitoring therapy response inglaucoma patients.