One goal of MDG's is againts HIV/AIDS, malaria and other infection disease. Now HIV/AIDS not only infects high risk population like MSM, injection drugs user, comercial sex worker, but also on woman and child, especially on poor woman. This articel used descriptive analitic method with logical thinking abot the fenomena of poor woman in HIV/AIDS case and the solution to solve them. The conclution of this articel is woman is more poor than man refers on economical and political perspective. It impacts that woman has more risk on HIV/AIDS than man because of biological, gender, social, economic, and cultural. Comprehensive efforts is needed from multi sector to decrease HIV/AIDS case on woman, such as (1) gender equility and woman empowerment, (2) Increase the access of health services for woman, and (3) Mentoring process to woman sex workir in preventing HIV/AIDS. Decision maker is important including gender equility issue in HIV/AIDS countermeasures program in each level from regency to national, and in health, education, and cultural, social, economy, and political and power sector