Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Cytotoxic and anti-Inflammatory activities of garcinia xanthochymus extracts on cell lines

Hanisuhana Hamidon; Muhammad Taher; Juliana Md Jaffri; Tg Muhamad Faris Syafiq tg Zakaria; Wan MAW Sulaiman; Deny Susanti; Solachuddin JA Ichwan ([Faculty of Pharmacy International Islamic University Malaysia;International Islamic University Malaysia. Faculty of Pharmacy;International Islamic University Malaysia. Faculty of Pharmacy;International Islamic University Malaysia. Faculty of Pharmacy, International Islamic University Malaysia. Faculty of Pharmacy], 2016)

 Abstrak

Objective: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti- inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusions: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.;

 Metadata

Jenis Koleksi : Artikel Jurnal
No. Panggil : J-Pdf
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Subjek :
Penerbitan : [Place of publication not identified]: [Faculty of Pharmacy International Islamic University Malaysia;International Islamic University Malaysia. Faculty of Pharmacy;International Islamic University Malaysia. Faculty of Pharmacy;International Islamic University Malaysia. Faculty of Pharmacy, International Islamic University Malaysia. Faculty of Pharmacy], 2016
Sumber Pengatalogan : LibUI eng rda
ISSN : 23563656
Majalah/Jurnal : Makara Journal of Health Research
Volume : Vol.20, No. 1, April 2016: 11-17
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Akses Elektronik :
Institusi Pemilik : Universitas Indonesia
Lokasi : Faculty of Pharmacy International Islamic University Malaysia
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J-Pdf 03-20-335614602 TERSEDIA
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