This paper proposes an approach in Southeast Asian studies using a post-colonial framework in the study of post-colonial Southeast Asia. This framework is based on the sociology of knowledge that analyzes the dialectical relationship between science, ideology, and discourse. Post-colonial studies is critical of the concept of universality in science and posits that a scientific statement of a society cannot stand alone, but is made by authors themselves who produce, use, and claim the so-called scientific statement. Several concepts in post-colonial theories can be used to develop area studies, i.e. colonial discourse, subaltern, mimicry, and hybridity. Therefore, this study also explores these concepts to develop a more comprehensive understanding of Southeast Asian culture. The development of post-colonial theories can be used to respond to the hegemony of social theories from Europe and the United States. The main contribution of area studies in the field of the social sciences and humanities is in revealing the hidden interests behind the universal social sciences.