ABSTRAK
Kojyl 3 APPA merupakan senyawa yang disintesis dari asam kojat dengan2,6oxazaphospory chlorida dengan 3-aminopropane phosphoric acid sebagaiprekursor. Kojyl 3 APPA memiliki kelarutan yang baik didalam air. Sifathidrofilik ini menyebabkan kojyl 3 APPA sukar berpenetrasi melalui kulit.Transfersom merupakan sistem pembawa yang dapat meningkatkan penetrasiefektivitas penghantaran obat. Penelitian ini bertujuan untuk memformulasi,mengkarakterisasi dan mengevaluasi sediaan transfersom yang mengandung kojyl3 APPA. Selanjutnya transfersom diformulasi dalam sediaan gel. Terhadapsediaan gel tersebut dilakukan uji stabilitas fisik dan uji penetrasi in vitro yangdibandingkan terhadap gel kojyl 3 APPA yang tidak dibuat transfersom. Sediaangel transfersom secara fisik terbukti stabil pada penyimpanan pada suhu kamar,suhu rendah dan suhu tinggi. Uji penetrasi in vitro menunjukkan penetrasi kojyl 3APPA dari sediaan gel transfersom sebesar 11,16% sedangkan untuk gel nontransfersom sebesar dan 8,02%.

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ABSTRACT
Kojyl 3 APPA is a compound synthesized from kojic acid with 2,6 oxazaphosporychloride with 3-aminopropane phosphoric acid as a precursor. Kojyl 3 APPA hasa good solubility in water. This causes the hydrophilic nature kojyl 3 APPAdifficult to penetrate through the skin. Transfersom is a carrier system that canimprove the effectiveness of drug penetration. This study aims to formulate,characterize and evaluate transfersom preparations containing kojyl 3 APPA.Furthermore transfersom formulated in a gel dosage form. Preparation gel was gelphysical stability test and penetration test in vitro against kojyl gel 3 APPA nontransfersom. Transfersom gel dosage form is physically proven stable in storage atroom temperature, low temperature and high temperature. In vitro penetrationtests show 3 kojyl APPA penetration show that penetration of kojyl 3 APPAloaded in transfersom was 11,16% while for non transfersom gel at 8,02%.