Indonesia Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 400-403Leukemia is myeloproliferative disorders characterized by differentiation and poliferation of malignantly transformed hematopoetic stem cells, leading to suppresion of normal cells, causing anemia, thrombocytopenia, and deficiency of normally functioning leukocytes. It has been classified as either acute or chronic and by cell type. The etiology of leukemia, in most cases, is unknown. Dental management consideration of the leukemic patient should include history, examination, and screening laboratory tests. This case report is about dental management needs on several cases of hospitalized leukemic patients. Most of the patients have bad oral hygiene and need an invasive dental treatment. Although, base on laboratory test and patient overall condition, these patients considered as high risk patients, the dentists should perform dental to prevent further oral infection severity.