Synectics Model matched with Mind Maps were applied in the instruction in order to achieve the target. This was an experimental quasi research with pre-test post-test control group design. The sample of the research was the eighth grade students of low and high academic levels in Makassar which was selected using cluster sampling random technique. Research data were analyzed using descriptive and inferential statistic of anacova. The results of analyses indicate that: (1) there was significance difference with the mean score of creative thinking ability, creative attitude, and mastery of biology materials due to difference of instruction model used, (2) there was no significant difference of mean score of creative think ability, creative attitude, and mastery of biology materials among the students who belong to the high and low academic level, ( 3) there was no interactional effect between the instructional model used with the students academic level towards creative thinking ability, creative attitude, and mastery of biology materials.