Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Anomaly protein of oral mucosal induces recurrent aphthous ulceration

(Journal of Dentistry Indonesia, 2004)


Recurrent Aphthous Ulceration (RAU) is a type of local inflammation of the oral mucosa with symptomatic soft tissue damage. The prevalence of RAU is about 17-67 %. Dominant factors causing this disease are understood, but there are predicted internal and external factors that cause related immune disorders. RAU is initiated by mucous proteins which continuously stimulate a physiological response required for a pathophysiological reaction. The aim of this study was to characterize specific anomaly proteins in oral mucosa as causing the initiation of RAU. Samples of mucosal proteins from 30 RAU patients were analyzed with sodium dodexylsulphate polyacrylamid gelelectrophorese (SDS-PAGE) and visualized with silver stain (AgNO3) showing proteins with a range of molecular weight 27 - 180 kDa. Western blotting using a polyclonal antibody specific to RAU showed that the specific proteins of RAU have molecular weights of 23, 27, 65, 70 and 87 kDa. The finding of so many proteins appears to be a new phenomenon, suggesting that the initiation of RAU is possibly due to a continuous induction of internal and external reactions by several mucosal proteins, that become anomaly proteins of high reactivity and antigenicity. This situation can cause overreaction on the oral mucosa with specific symptoms that are known as a RAU.

 File Digital: 1


Jenis Koleksi : Artikel Jurnal
No. Panggil : pdf
Subjek :
Penerbitan : [Place of publication not identified]: Journal of Dentistry Indonesia, 2004
Sumber Pengatalogan :
Majalah/Jurnal : Journal of Dentistry Indonesia
Volume : Vol. 11, No. 1, April 2004: 13-16
Tipe Konten :
Tipe Media :
Tipe Carrier :
Akses Elektronik :
Institusi Pemilik : Universitas Indonesia
Lokasi :
  • Ketersediaan
  • Ulasan
  • Sampul
No. Panggil No. Barkod Ketersediaan
Tidak ada ulasan pada koleksi ini: 20437122