Endo-perio lesion cound occur due to the close relationship between the pulp and the periodontium. Therefore, pulpal lesion could cause a periodontium lesion. To decide on an appropriate diagnosis, a thorough and careful examination needs to be done in order to determine the right treatment. Most of the endo-perio cases should be approached with a root canal treatment because the source of the lesion is in the canal and there is a possibility of healing of the periapical and periodontal ligament without surgical intervention. A report of a healing of an endo-perio case without surgical approach will be discussed.