Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Cellular responses to DNA damage and oncogenesis by the p53 and pRb/E2F pathways

Elza Ibrahim Auerkari, Ismu Suharsono Suwelo, Achmad Tjarta, Santoso Cornain, T. W. Rahardjo, K. Eto, M.A. Ikeda (Journal of Dentistry Indonesia, 2003)

 Abstrak

Cellular responses to stress including DNA damage show multiple options involving the mechanisms of growth arrest, DNA repair and programmed cell death or apoptosis. Failures in these mechanisms can result in oncogenesis or accelerated senescence. Much of the response is coordinated by p53, a nuclear phosphoprotein with a central role in the defences against physical, chemical and pathogenic agents which challenge the DNA integrity. The p53 pathways for mobilising the cellular defences are linked to the pRb/E2F pathways regulating the cell cycle progression. This paper aims to review the current understanding on the networks and main molecular machinery of these processes. In addition, the implications on cellular decision making for the defences as well as evolutionary aspects of these mechanisms are discussed in brief.

 File Digital: 1

 Metadata

Jenis Koleksi : Artikel Jurnal
No. Panggil : AJ-Pdf
Entri tambahan-Nama orang :
Subjek :
Penerbitan : Jakarta: Journal of Dentistry Indonesia, 2003
Sumber Pengatalogan : LibUI eng rda
ISSN : 0854364X
Majalah/Jurnal : Journal of Dentistry Indonesia
Volume : Vol. 10, No. 2, Agustus 2003: 406-415
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Akses Elektronik :
Institusi Pemilik : Universitas Indonesia
Lokasi :
  • Ketersediaan
  • Ulasan
  • Sampul
No. Panggil No. Barkod Ketersediaan
AJ-Pdf 03-19-747844290 TERSEDIA
Ulasan:
Tidak ada ulasan pada koleksi ini: 20437952
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