Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Peran p53 sebagai jalur kritis pada mekanisme kontrol siklus sel sebagai pencegah terjadinya kanker mulut./ Herlia Nur Istindiah, Elza Ibrahim Auerkari

Herlia Nur Istindiah; ([Journal of Dentistry Indonesia, Journal of Dentistry Indonesia], 2002)

 Abstrak

In cell cycle control, p53 acts as an emergency brake, where its important checkpoint function is to maintain the genome integrity by preventing the formation and proliferation of mutant cells. P53 activity is increased by DNA damage occurs caused by agents (such as radiation, UV light or drugs) or oncogenes. Mdm2 protein can inhibit the p53 activation, but oncogenes can inhibit Mdm2 or activate p53. If DNA damage occurs, then p53 prevents the cells from replicating their DNA by arresting the cell cycle, so that the cells can repair the damage. Alternatively, p53 instructs the cells to undergo apoptosis by inducing bax gene expression, so that irregular cell growth, and cancer can be avoided. Cancer, including oral cancer, oftenthuolved cells with altered p53. Exogenous factors, such as tobacco and alcohol, presumably plays a role in triggering p53 mutations. Several techniques, such as immunohistochemistry and PCR can be used to investigation ther etiology and development of oral cancer. This paper discusses the role on p53 in preventing the occurrance and proliferation of mutated cells that lead to cancer, including oral cancer.

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 Metadata

Jenis Koleksi : Artikel Jurnal
No. Panggil : PDF
Entri utama-Nama orang :
Subjek :
Penerbitan : [Place of publication not identified]: [Journal of Dentistry Indonesia, Journal of Dentistry Indonesia], 2002
Sumber Pengatalogan :
ISSN : 23554800
Majalah/Jurnal : Universitas Prof. Moestogo, Fakultas Kedokteran Gigi
Volume : Vol. 9, No. 2, Agustus 2002: Hal. 30-34
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource (carrierrda)
Akses Elektronik : http://www.jdentistry.ui.ac.id/index.php/JDI/article/view/679
Institusi Pemilik : Universitas Indonesia
Lokasi :
  • Ketersediaan
  • Ulasan
  • Sampul
No. Panggil No. Barkod Ketersediaan
PDF 03-17-819869405 TERSEDIA
Ulasan:
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