Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Cytotoxic and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines / Hanisuhana Hamidon, Muhammad Taher, Juliana Md Jaffri, Tg Muhamad Faris Syafiq Tg Zakaria, Wan MAW Sulaiman, Deny Susanti, Solachuddin JA Ichwan, Zainul A Zakaria

Hanisuhana Hamidon (International Islamic University Malaysia. Faculty of Pharmacy ; International Islamic University Malaysia. Faculty of Science ; International Islamic University Malaysia. Faculty of Dentistry ; Universiti Putra Malaysia. Faculty of Medicine and Health Sciences, 2016)

 Abstrak

Objective: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study
was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines.
Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane
and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using
MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide
production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and antiinflammatory
study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic
activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark
dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner.
Conclusions: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of
cancer and inflammation.

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Jenis Koleksi : Artikel Jurnal
No. Panggil : PDF
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Penerbitan : [Place of publication not identified]: International Islamic University Malaysia. Faculty of Pharmacy ; International Islamic University Malaysia. Faculty of Science ; International Islamic University Malaysia. Faculty of Dentistry ; Universiti Putra Malaysia. Faculty of Medicine and Health Sciences, 2016
Sumber Pengatalogan : LibUI eng rda
ISSN : 23563656
Majalah/Jurnal : Makara Journal of Health Research
Volume : Vol. 20, No. 1, April 2016: Hal. : 11-17
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Akses Elektronik : http://journal.ui.ac.id/index.php/health/article/view/5599
Institusi Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 4, R. Koleksi Jurnal
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