Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Analysis expression of ZIP1 and caspase-3 protein in adenocarsinoma of the prostate / Aditya D Septiawan, Ria Kodariah, Meilania Saraswati

Aditya D. Septiawan; Meilania Saraswati (Fakultas Kedokteran Universitas Indonesia, 2016)

 Abstrak

Objective: Carcinogenesis of adenocarcinoma of the prostate occurs due to dysregulation of zinc level within the cells.
Intracellular zinc molecules influx is regulated by a transporter protein ZIP1, whose non-presence is predicted to inhibit
apoptosis, thus leads to the development of prostate adenocarcinoma. Methods: This study was aimed to analyze the
correlation of ZIP1 and Caspase-3 expression in prostate adenocarcinoma on its grading as represented by Gleason
Score. This was a cross-sectional, retrospective analytical study on 31 formalin-fixed, paraffin-embedded tissue that
meets inclusion criteria. The specimen was stained using the immune-histochemistry technique for ZIP1 and Caspase-3.
Protein expression of each case was counted using ImageJ analysis. Gleason score was acquired as secondary data from
the cases’s reports. The correlation of their expression with respect to Gleason score was analyzed with Pearson’s
correlation using SPSS 11.5. Results: Mean expression level of ZIP1 and Caspase-3 in prostate adenocarcinoma were
35% and 33%, respectively. There was a significantly positive correlation between ZIP1 and Caspase-3 expression
(r = 0.379; p = 0.018). However, their correlation was stronger in intermediate-grade group (r = 0.73; p = 0.01) and the
correlation was much weaker in high-grade group (r = 0.04; p = 0.48). Conclusions: There was a positive correlation
between ZIP1 and Caspase-3 expression in prostate adenocarcinoma.

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Jenis Koleksi : Artikel Jurnal
No. Panggil : PDF
Entri utama-Nama orang :
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Penerbitan : [Place of publication not identified]: Fakultas Kedokteran Universitas Indonesia, 2016
Sumber Pengatalogan : LibUI eng rda
ISSN : 23563656
Majalah/Jurnal : Makara Journal of Health Research
Volume : Vol. 20, No. 1, April 2016: Hal. : 18-22
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Akses Elektronik : http://journal.ui.ac.id/index.php/health/article/view/5601
Institusi Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 4, R. Koleksi Jurnal
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