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A Comprehensive Study of Chronic Diabetes Complications in Streptozotocin-Induced Diabetic Rat

by Sinan M. A. Al-Mahmood... [and others] ([Publisher not identified] , 2016)

 Abstract

The purpose of this study was to provide a reference of chronic diabetes complications by investigating the prolonged hyperglycemia effects on hematological, biochemical and histopathological changes (liver, kidney, spleen, cardiac muscle, adrenal gland, and endocrine pancreas) in diabetic rats induced by streptozotocin.
Methods: Ten adult female Sprague-Dawley of uniform age were divided into two Groups. Group 1 was made diabetic by single intraperitoneal injection of streptozotocin (60 mg/kg/bw) whereas Group 2 served as control. After six months, the rats were anesthetized using pentobarbital. Cardiac puncture was performed to get 3 ml of the blood sample; following 12 hours of an overnight fast. Serum chemistry test and complete blood analysis for lipid profile and blood glucose test; liver and renal functions were performed. Tissue specimens of liver, kidney, spleen, cardiac muscle, adrenal gland, and endocrine pancreas were fixed in 10% formal saline and processed for histological study.
Results: There were severe histopathological changes in the affected organs; and the presence of a significant abnormality of lipid profile, liver, and renal functions.
Conclusions: The presence of histopathological changes with abnormal biochemical changes is related to the chronic absence of insulin production in the destroyed β ?cells which reflect the diabetic complications in a human being.

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Collection Type : Artikel Jurnal
Call Number : PDF
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Publishing : [Place of publication not identified]: [Publisher not identified], 2016
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ISSN : 23563656
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Volume : Vol 20, No 2 August 2016 48-56
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Electronic Access : http://journal.ui.ac.id/index.php/health/article/view/5889
Holding Company : Universitas Indonesia
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Call Number Barcode Number Availability
PDF 03-19-520119628 TERSEDIA
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No review available for this collection: 20443385
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