Chronic Kidney Disease merupakan kumpulan sindrom klinik dengan penurunan fungsi ginjal progresif. Prevalensi fatigue tinggi pada pasien hemodialisis. Penelitian ini bertujuan menjelaskan faktor yang berhubungan dengan Fatigue pada pasien yang menjalani hemodialisis. Desain penelitian analitik observasional. Teknik non probability sampling. Hasil penelitian tidak ada hubungan tingkat fatigue dengan pekerjaan (p= 0,732; α= 0,05), status dukungan (p= 0,679; α= 0,05), jenis kelamin (p= 0,914; α= 0,05), frekuensi (p= 0,676; α= 0,05), jarak fasilitas (p= 0,149; α= 0,05), komplikasi (p= 0,062; α= 0,05), merokok (p= 0,062; α= 0,05), alkohol (p= 0,075; α= 0,05), riwayat penyakit (p= 0,42; α= 0,05), dan status nutrisi (p= 0,168; α= 0,05). Ada hubungan tingkat fatigue dengan latihan fisik (p= 0,027; α= 0,05), lama menjalani hemodialisis (p= 0,019; α= 0,05), kadar hemoglobin (p= 0,029; α= 0,05), penghasilan (p= 0,07; α= 0,05), dan pendidikan (p= 0,040; α= 0.05). Faktor dominan adalah penghasilan. Perawat hemodialisis diharapkan memonitoring fatigue, memberikan pendidikan kesehatan tentang latihan fisik dan memberikan asuhan keperawatan holistik.

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Chronic Kidney Disease is set of clinic syndrome with progressive degradation of kidney function. High Prevalent fatigue at patient hemodialysis. This Research was aimed to explain the factor related to fatigue in patients undergoing hemodialysis. This Research was observational analytic research. Technique sample was non probability sampling Research result was norelation between level fatigue and job status (p= 0.732; α= 0.05), gender (p= 0.914; α= 0.05), support status (p= 0.679; α=0.05), frequency (p= 0.676; α= 0.05), facility distance (p= 0.149; α= 0.05), complication (p= 0.062; α= 0.05), smoking habits(p= 0.062; α= 0.05) and alcohol habits (p= 0.075; α= 0.05), disease history (p= 0.42; α= 0.05), nutrition status (p= 0.168;α= 0.05). There was relation between level fatigue and physical exercises (p= 0.027; α= 0.05), duration of hemodialysis (p=0.019; α= 0.05) and level of hemoglobin (p= 0.029; α= 0.05), income (p= 0.07; α= 0.05), and education level (p= 0.040; α=0.05). The dominant factor was income. Hemodialysis nurses are expected monitor fatique and give health education about physical practice and give holistic nursing care.