Many diseases can have an impact upon oral health and/​or the safe delivery of dental care. Consequently, oral health care providers need to be comfortable with assessing the risk of providing dental care to their patients with systemic disease as well as the evaluation of oral conditions that may represent manifestations or consequences of systemic disease. Risk Assessment and Oral Diagnostics in Clinical Dentistry aims to enable the dental practitioner to comfortably and capably assess when medical conditions may impact dental care and diagnose oral conditions using routine testing.