As a prolactin antagonist, dopamine binds to its receptor D2 and suppresses the secretion of prolactinfrom the pituitary gland. Required ligand that can interact with receptor so that dopamine can nolonger bound to its receptor. Ligands empirically derived from plants and have been proven toincrease human lactation. In silico study using molecular docking technique to identify ligandinteraction with dopamine D2 receptor (PDB: 1I15). The best posing and binding energy (ΔG) wereanalyzed and ranked to get potential dopamine D2 receptor inhibitor. Binding energy of apigenin,luteolin, kaempferol, quercetin, and myricetin with PDB: 1I15 gives value respectively -5.90, -5.67, -5.64, -5.28, -4.36 kcal/mol. Interaction occurred between the ligand and amino acid residue ASN 192,PRO 204, SER 209 formed hydrogen bonding and hydrophobic interaction with HIS 189.