This book aims to present the first comprehensive synthesis of the context and impact of non-communicable diseases (NCDs) in low- and middle-income countries (LMICs) and to offer insights on successful and sustainable interventions and policies that work for at-risk populations. It includes 12 chapters divided into 3 parts. Part I focuses on the state of the problem and state of knowledge on the epidemiology and burden of the major NCDs. Three chapters review the epidemiology and burden of cardiovascular diseases and diabetes (Chapter 1), cancers (Chapter 2) and neurodegenerative diseases such as dementia and Parkinson's disease (Chapter 4). Two chapters focus on the co-morbid and multi-morbid interactions between the major NCDs and infectious diseases like HIV, tuberculosis and malaria (Chapter 3) and mental health disorders (Chapter 5). Part II focuses on best practices and innovation in research and intervention. Four chapters discuss key issues on this theme including health systems strengthening (Chapter 6), population surveillance (Chapter 7), community-based interventions (Chapter 8) and self-help approaches to NCD care (Chapter 9). Part III focuses on policy development and implementation. Three chapters offer a comprehensive analysis of existing policies relevant to NCD prevention and control. They focus on policies that work, as well as discussing the lessons that can be learned from infectious disease control (Chapter 10), NCD control in high-income countries (Chapter 11) and the current policy issues and activities arising from the 2011 UN High Level Meeting on NCDs and leading to a post-2015 global health agenda (Chapter 12).