This research discribes about time service analysis of compounding and non compounding medicines in hermina with lean sigma approach ininstallation of outpatient in hermina depok. Pharmacy time service is the important part of the hospital excellent services and lean six sigma is a methodology of decreasing the waste and variation. Thjs reaserch is a an operational research where the researcher did a direct counting in each process of compounding and non compounding prescriptions. Lean six sigma method which has been used were define, measure, analyze and improve. This reaserch aims to propose a better visual management application, 5s culture, lay out changing and electronic prescription and heijunka prescription as a long term porpuse. Using of lean six sigma method could decrease the waste of non compounding prescription service from 43 procedures to 32 procedures with time allocation from 31 minutes and 51 seconds to 16 minutes 34 seconds. For the compounding prescription could also decrease the procedures, from 32 steps to 46 steps with time allocationfrom 47 minutes and 31 seconds to 25 minutes and 7 seconds.