Latar belakang: Peningkatan enzim transaminase sering ditemukan pada anak dengan leukemia limfoblastik akut LLA dalam kemoterapi fase pemeliharaan. Belum ada penelitian terkait pemberian vitamin E pada anak LLA dengan kondisi tersebut di Indonesia. Tujuan: Mengetahui prevalens, karakteristik, dan pengaruh pemberian vitamin E terhadap perbaikan kadar enzim transaminase pada anak LLA dalam kemoterapi fase pemeliharaan. Metode: Uji klinis acak tersamar tunggal, membandingkan vitamin E dosis antioksidan dengan plasebo pada anak LLA yang mengalami peningkatan enzim transaminase bulan Agustus-Desember 2017 di Poliklinik Hematologi dan Onkologi Rumah Sakit Cipto Mangunkusumo. Enzim transaminase dievaluasi setelah 3 dan 5 minggu intervensi dan perbaikan didefinisikan bila menurun ge;20. Hasil: Terdapat 33 kejadian peningkatan enzim transaminase, 17 vitamin E dan 16 plasebo. Prevalens 41,2, karakteristik pasien predominan laki-laki, usia 2,5-5x. Vitamin E dibandingkan plasebo setelah 3 minggu P=0,601; RR=0,93; IK 95 0,73-1,16 dan 5 minggu P= 0,103; RR= 0,81; IK 95 0,64-1,03. Kesimpulan: Pemberian Vitamin E dibandingkan plasebo pada anak LLA dalam kemoterapi fase pemeliharaan setelah 3 dan 5 minggu tidak berbeda bermakna, namun kelompok vitamin E terdapat kecenderungan perbaikan kadar enzim transaminase.

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Background: Aminotransferase enzyme's elevation is a common complication associated maintenance chemotherapy in pediatric acute lymphoblastic leukemia ALL. Vitamin E is used as therapy but none research has been done on this issue in Indonesia.

Objectives: To identify the prevalence, characteristics of patients and the effect of vitamin E on aminotransferase enzyme's improvement in pediatric ALL during maintenance chemotherapy.

Methods: A randomized single blind controlled trial of antioxidant dose vitamin E versus placebo in pediatric ALL during maintenance chemotherapy with aminotransferase enzyme's elevation was conducted on August December 2017 at Hematology and Oncology clinic Cipto Mangunkusumo hospital. Aminotransferase enzymes were evaluated after intervention for 3 and 5 weeks. Improvement was defined as a decrease ge 20 of baseline.

Results: There were 33 events, 17 vitamin E and 16 placebo. Prevalence was 41,2, characteristics were predominated boys, 2,5 5x. There were no statistical difference in aminotranferase enzyme's improvement after 3 weeks intervention P 0,601 RR 0,93 CI 95 0,73 1,16 and 5 weeks intervention P 0,103 RR 0,81 CI 95 0,64 1,03.

Conclusion Antioxidant dose of vitamin E tends to decrease aminotransferase enzyme but not statistically significant.