Keberadaan benzena dalam lem alas kaki ini membahayakan kesehatan para pekerjadi bengkel alas kaki karena sifatnya yang toksik dan karsinogenik. Dampak yangditimbulkan adalah terganggunya sumsum tulang yang merupakan tempat produksi seldarah merah; darah putih dan trombosit. Tujuan dari penelitian ini adalah menganalisishubungan pajanan benzena melalui pemeriksaan konsentrasi S-phenylmercapturic acid S-PMA di urin terhadap kadar trombosit pada pekerja bengkel alas. Desain daripenelitian adalah cross sectional pada pekerja pabrik alas kaki di Desa Sukajaya denganjumlah sampel 73 pekerja. Sampel yang diambil adalah urin dan darah dari pekerjauntuk mengetahui konsentrasi S-PMA dan kadar trombosit. Konsentrasi S-PMA diukurdengan alat LC-MS/MS dan trombosit dengan Automated Hematology Analyzer.Karakteristik individu dengan wawancara secara langsung. Hasil penelitianmenunjukkan nilai OR=2,28 antara konsentrasi S-PMA terhadap kadar trombosit.Variabel kebiasaan olahraga dengan OR=1,58 antara olahraga tidak rutin terhadaptrombosit dan konsumsi alkohol OR=1,78 antara yang mengkonsumsi terhadap kadartrombosit. Hasil uji regresi logistik multivariabel menunjukkan nilai OR=2,59 pekerjadengan konsentrasi S-PMA >0,67 g/g kreatinin terhadap kadar trombosit setelahdikontrol variabel umur dan konsumsi alkohol.

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The existence of benzene in the glue of footwear is endangering the health of theworkers in the footwear workshop because of its toxic and carcinogenic nature. Theimpact is the disruption of the bone marrow which is where the production of red bloodcells; white blood and platelets. The purpose of this study was to analyze therelationship of benzene exposure through the examination of S phenylmercapturic acid S PMA concentration in urine on platelet levels in base workshop workers. The designof the study was cross sectional on footwear factory workers in Sukajaya Village with asample of 73 workers. Samples taken are urine and blood from workers to know theconcentration of S PMA and platelet levels. The concentration of S PMA was measuredby LC MS MS and platelets with Automated Hematology Analyzer. Individualcharacteristics with direct interview. The results showed the value of OR 2.28between S PMA concentration to platelet level. Variables of exercise habits with OR 1.58 between non routine exercise on platelets and alcohol consumption OR 1.78among those who consume to platelet levels. Multivariable logistic regression testresults showed OR 2.59 workers with S PMA concentration 0.67 g g creatinine on platelet count after controlled for age and alcohol consumption.