Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

A Multicentre surveillance study on the characteristics, bacterial aetiologies and in vitro antibiotic susceptibilities in patients with acute exacerbations of chronic bronchitis

Erlina Burhan; Hui, David S; Ling, Thomas; Chang, Shan-Chwen; Margaret IP; Liao, Chun-Hsing; Pratiwi Pudjilestari Sudarmono; Priyanti Soepandi; Fathiyah Isbaniah; Hadiarto Mangunnegoro (Asian Pacific Society of Respirology, 2011)

 Abstrak

Background and objective: Antimicrobial resistance is a global problem and the prevalence is high in many Asian countries.
Methods: A prospective observational study of the prevalence of bacterial pathogens and their antimicro-bial susceptibilities in patients with acute exacerba-tions of chronic bronchitis (AECB) was conducted in Indonesia, Philippines, Korea, Thailand, Malaysia, Taiwan and Hong Kong from August 2006 to April 2008. The diagnosis of AECB was based on increased cough and worsening of two of following: dyspnoea, increased sputum volume or purulence. Patients who had taken antibiotics within 72 h of presentation were excluded. All bacterial strains were submitted to a central labo-ratory for re-identification and antimicrobial suscepti-bility testing to 16 antimicrobial agents according to Clinical and Laboratory Standards Institute.
Results: Four hundred and seven isolates were iden-tified among 447 patients of AECB. The most frequent organisms isolated were Klebsiella pneumoniae and associated species (n = 91 + 17), Haemophilus influen-zae (n = 71), Pseudomonas aeruginosa (n = 63), Streptococcus pneumoniae (n = 32), Acinetobacter baumannii (n = 22) and Moraxella catarrhalis (n = 21). According to Clinical and Laboratory Standards Insti-tute susceptibility breakpoints, 85.7% and >90% of these pathogens were susceptible to levofloxacin and cefepime respectively. Other options with overall lower susceptibilities include imipenem, ceftazidime, ceftri-axone and amoxicillin/clavulanate.
Conclusions: Gram-negative bacteria including Kleb-siella spp., P. aeruginosa and Acinetobacter spp. consti-tute a large proportion of pathogens identified in patients with AECB in some Asian countries. Surveil-lance on the local prevalence and antibiotic resistance of these organisms is important in guiding appropriate choice of antimicrobials in the management of AECB.

 Metadata

Jenis Koleksi : Artikel Jurnal
No. Panggil : MK-pdf
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Subjek :
Penerbitan : [Place of publication not identified]: Asian Pacific Society of Respirology, 2011
Sumber Pengatalogan : LibUI eng rda
ISSN :
Majalah/Jurnal : Respirology
Volume : Respirology (2011) 16, pages 532-539
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resource
Akses Elektronik :
Institusi Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
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No. Panggil No. Barkod Ketersediaan
MK-pdf 03-18-496704623 TERSEDIA
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Tidak ada ulasan pada koleksi ini: 20480064
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