UI - Disertasi Membership :: Kembali

UI - Disertasi Membership :: Kembali

Penilaian efektivitas dan dermatofarmakokinetik krim pelembap minyak kelapa untuk pencegahan sekunder dermatitis-tangan akibat kerja pada perajin batik = Effectiveness and dermatopharmacokinetic of moisturizer containing cocos nucifera L. and glycerin for secondary prevention of hand dermatitis among batik workers

Windy Keumala Budianti; Rustarti Retno Widowati Soebaryo, promotor; Muchtaruddin Mansyur, co-promotor; Joshita Djajadisastra, co-promotor; Suhendro, examiner; Franciscus D. Suyatna, examiner; Siagian, Minarma, examiner; Cita Rosita Sigit Prakoeswa, examiner (Fakultas Kedokteran Universitas Indonesia, 2019)


Batik workers are a group at highest risk of acquiring occupational contact
dermatitis, especially hand dermatitis. Prevention of using personal protective
equipment (PPE) does not provide optimal protection therefore other interventions
are needed for secondary prevention. The development of topical agents that
improve skin barrier function is a promising approach for the management of
hand dermatitis. Topically applied lipids and humectants may interfere with skin
barrier function, and facilitate skin barrier repair. The aim of this study is to
evaluate the effectiveness of Cocos nucifera and glycerine for secondary
prevention of hand dermatitis among batik workers.
In a double-blind, cross-over randomized study, the effect of glycerine coconut
oil-containing cream vs. glycerine alone on skin barrier functions was determined
by assessment after repeated application of moisturizers over a 2-week period in
batik workers with occupational hand dermatitis. As much as 32 batik dyeing
and/or rinsing process workers were enrolled in this study for a minimum of 6
months with mild to moderate occupational hand dermatitis. Assessment of
transepidermal water loss (TEWL), skin capacitance and the Hand Eczema
Severity Index (HECSI) were made at baseline and day 14.
The research showed that the type of hand dermatitis among subjects that occurs
were 56 palmar hyperkeratosis, 15.6 interdigital eczema, 12.5 nummular
hand eczema, 9.4 pulpitis and 6.3 recurrent vesicular hand eczema. As much
as 96.97 of the subjcts have nail discoloration. 40.6 of the subjects always use
PPE were at risk of developing hand dermatitis.
After applying 14 days, both moisturizers showed clinical improvement by 20
decreased of HECSI and TEWL and 20 increased of skin capacitance. There
was no statistically significant treatment effect between both moisturizers. Skin
stripping result was analyzed using chromatography method showed penetration
at 3rd hour (uptake) and still detected at 12th hour (clearance).
The findings of the study support the skin health program for batik workers and
routine usage of moisturizers are recommended for a minimal of 12 hours per day
to prevent hand dermatitis.

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Jenis Koleksi : UI - Disertasi Membership
No. Panggil : D-Pdf
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Penerbitan : Depok: Fakultas Kedokteran Universitas Indonesia, 2019
Physicsxxix, 160 pages : illustration; 30 cm + appendix
Formatonline resource
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D-Pdf 07-19-605444183 TERSEDIA
Tidak ada ulasan pada koleksi ini: 20485970