Sikap kesehatan reproduksi remaja dipengaruhi oleh beberapa faktor, salah satunya adalah jenis sekolah. Penelitian ini bertujuan untuk mengetahui perbedaan sikap kesehatan reproduksi siswa antara SMA negeri dan SMA berbasis agama. Penelitian ini menggunakan desain kuantitatif komparatif dengan pendekatan cross sectional. 104 responden dari SMA di Depok diperoleh dengan menggunakan teknik cluster random sampling. Hasil analisis chi square menunjukkan ada perbedaan yang signifikan antara sikap kesehatan reproduksi siswa SMA negeri dan SMA berdasarkan agama (p = 0,000, CI 95%). Perbedaan tersebut dapat terjadi karena pengaruh tingkat religiusitas, lingkungan sekolah dan teman sebaya. Hasil ini merekomendasikan adanya peningkatan program pendidikan kesehatan reproduksi di sekolah menengah atas melalui pendekatan pendidikan agama.The attitude of adolescent reproductive health is influenced by several factors, one of which is the type of school. This study aims to determine the differences in the reproductive health attitudes of students between state high schools and religion-based high schools. This study used a comparative quantitative design with a cross sectional approach. 104 respondents from SMA in Depok were obtained using cluster random sampling technique. The results of the chi square analysis showed that there was a significant difference between the reproductive health attitudes of public high school and senior high school students based on religion (p = 0.000, 95% CI). These differences can occur due to the influence of the level of religiosity, school environment and peers. These results recommend an increase in reproductive health education programs in senior secondary schools through the religious education approach.