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Groundwater plays an important role as a source of fulfillment of daily clean water and drinking water in Depok City. Groundwater is considered to have good natural qualities, but that does not mean that all groundwater is good quality. Iron and manganese are essential but also toxic metals that are often found in groundwater. This study uses the Environmental Health Risk Assessment (EHRA) method which aims to estimate the level of iron and manganese risk exposure in groundwater as drinking water. Data collection of iron and manganese concentration was obtained from groundwater quality survey results by BPP PDAM Tirta Asasta Depok City in 2018 as many as 63 samples. Other data, anthropometry, activity rates, and drinking water consumption rates were obtained from interviews using questionnaires and measurement of body weight directly in the homes of 63 respondents. The result of the analysis of iron and manganese concentration showed that there were 18 samples that exceeded the standar quality of manganese according to Permenkes 492/2010. The estimated amount of iron and manganese intake is 5,02059 x 10-4 mg/kg/day and 5.52265 x 10-3 mg/kg/day, respectively. Whereas non-carcinogenic RQ of iron and manganese were 0,00072 and 0,03945 respectively which indicated that they were safe. Further analysis found that daily intake of iron and manganese according to age and sex categorized as deficiency (intake of iron and manganese