This book gathers the proceedings of the I-ESA 18 Conference, which was organised by the Fraunhofer IPK, on behalf of the European Virtual Laboratory for Enterprise Interoperability (INTEROP-VLab) and the DFI, and was held in Berlin, Germany in March 2018. It presents contributions ranging from academic research and case studies, to industrial and administrative experiences with interoperability that show how, in a globalised market scenario-where the ability to cooperate with other organisations efficiently is essential in order to remain economically, socially and environmentally cost-effective-the most innovative digitised and networked enterprises ensure that their systems and applications can interoperate across heterogeneous collaborative networks of independent organisations. Furthermore, the content addresses smart services, and the business impact of enterprise interoperability on organisations.