Latar belakang: Peningkatan usia lanjut menimbulkan dampak kesehatan, diantaranya adalah sarkopenia dan kerapuhan. Kekuatan genggam tangan merupakan komponen sarkopenia, fenotip sindrom kerapuhan, dan bersifat dinamis. Berbagai studi potong lintang menilai hubungan kekuataan genggam tangan dengan usia, jenis kelamin, status nutrisi, status fungsional, status mental, dan komorbiditas namun temuan masih beragam. Selain itu, belum ada studi longitudinal untuk mengetahui hubungan perubahan kekuatan genggam tangan dengan usia, jenis kelamin, status nutrisi, status fungsional, status mental dan komorbiditas di Indonesia.Tujuan: Mengetahui hubungan antara usia, jenis kelamin, status nutrisi, status fungsional, status mental dan komorbiditas dengan perubahan kekuatan genggam tangan pada pasien usia lanjut.Metode: Penelitian kohort prospektif menggunakan data sekunder pasien usia lanjut yang kontrol rutin di Poliklinik Geriatri RSCM Jakarta dari register studi longitudinal INA-FRAGILE yang telah diobservasi selama 1 tahun (2013-2014). Uji analisis multivariat regresi logistik digunakan untuk menilai hubungan antara usia, jenis kelamin, status nutrisi (skor MNA), status fungsional (skor ADL), status mental (skor GDS-SF), indeks komorbiditas (skor CIRS) dengan perubahan kekuatan genggam tangan.Hasil: Dalam 1 tahun pengamatan dari 162 subjek, didapatkan rerata usia 72,9 (SB 5,9) tahun, jenis kelamin terbanyak perempuan (57,41%), memiliki nutrisi baik (83,9%), mandiri (median ADL 9–20), tidak depresi (median GDS-SF 0–11), rerata indeks komorbiditas 11,8 (SB 3,7), dan 53,1% mengalami penurunan kekuatan genggam tangan. Status nutrisi (OR=2,7; p=0,033) dan indeks komorbiditas (OR 0,3; p<0,002) berhubungan dengan kekuatan genggam tangan.Simpulan: Status nutrisi dan komorbiditas memengaruhi perubahan kekuatan genggam tangan pada pasien usia lanjut dalam 1 tahun di rawat jalan.

---

Background: Increasing elderly population throughout the world has been related to increased prevalence of sarcopenia and frailty. Handgrip strength is a component of sarcopenia, one of frailty syndrome phenotypes, and a dynamic process. Previous cross-sectional studies have assessed association of age, sex, nutritional status, functional status, mental status and comorbodity but the results were varied. That being said, there was no longitudinal study has been done to determine the correlation of handgrip strength changes with age, sex, nutritional status, functional status, mental status, and comorbidity in Indonesia.

Objective: To examine correlation between age, sex, nutritional status, functional status, depressive symptopms, comorbidity, and handgrip strength changes in elderly patients.

Methods: A prospective cohort study using secondary data of elderly patients whom routinely visiting Geriatric Out-Patients Clinic at Cipto Mangunkusumo Hospital, Jakarta from INA-FRAGILE register that have been observed for 1 year (2013-2014). The multivariate logistic regression analysis was used to assess correlation between sex, age, nutrional status (MNA score), functional status (ADL score), depressive symptoms (GDS-SF score), comorbidities (CIRS score) and handgrip strength changes.

Results: From 162 subjects which were included in the study, the mean age was 72.9 (SB 5.9) years, predominantly female (57.41%), with good nutrition (83.9%), independent (median 9- 20), not depressed (median 0-11), has average comorbidity index 11.8 (SB 3.7), and 53.1% experienced decreased handgrip strength. Nutritional status (OR = 2.7, p = 0.033) and comorbidity index (OR 0.3, p <0.002) correlated with handgrip strength changes.

Conclusion: Nutritional status and comorbidity correlates with handgrip strength changes in out-patients elderly within 1 year.