Patient safety is one of the five crucial hospital safety issues. This study aimed to determine factors related with nurses’ compliance in the implementation of indicators of patient safety goals (IPSG 1, IPSG 2, IPSG 5, and IPSG 6). This study was a descriptive correlative with a cross-sectional approach. Samples were recruited using a purposive sampling technique (n = 102). Data were analyzed using chi-square and Mann–Whitney tests. The results of this study indicate that the leadership style of the head nurse, rewards, attitudes, and motivation had a significant relationship with the level of adherence in the implementation of IPSG 1 and IPSG 2. The level of nurses’ compliance in the implementation of IPSG 5 was only influenced by the leadership style of the room head and the nurses’ positive attitude. None of the factors had significant relationships with the level of nurses’ compliance in the implementation of IPSG 6. The consultative leadership style of the room head can change the level of nurses’ compliance in the implementation of IPSG 1 by 5.6 times, with 5.06 times toward IPSG 2 and 4.71 times toward IPSG 5. This research recommends the need for consultative leadership style from the room head to carry out the roles and functions as a supervisor to improve associate nurses’ compliance in the implementation of IPSG 1, IPSG 2, IPSG 5, and IPSG 6.