Latar Belakang: Karies gigi merupakan masalah kesehatan yang banyak terjadi di dunia. Saliva memiliki berbagai peran di dalam rongga mulut yang berhubungan dengan karies. Total Antioxidant Capacity berperan dalam melindungi tubuh dari berbagai kondisi patologis. Tujuan: Menganalisis konsentrasi Total Antioxidant Capacity pada saliva bebas karies dan early childhood caries dihubungkan dengan OHI-S, dmf-t, serta viskositas dan laju alir saliva. Metode: Sampel saliva tersimpan sebanyak 33 sampel yang diperoleh dari anak usia di bawah 71 bulan dengan kondisi bebas karies dan early childhood caries diuji dengan menggunakan total antioxidant capacity assay kit. Hasil: Terdapat perbedaan konsentrasi Total Antioxidant Capacity dalam saliva anak bebas karies dan early childhood caries, terdapat korelasi linier positif sedang antara konsentrasi Total Antioxidant Capacity dalam saliva anak dengan skor dmf-t, tidak terdapat perbedaan konsentrasi Total Antioxidant Capacity dalam saliva anak dengan kategori OHI-S baik dan sedang, laju alir saliva tinggi dan sedang, serta viskositas saliva encer dan kental. Kesimpulan: Konsentrasi Total Antioxidant Capacity pada saliva early childhood caries lebih tinggi dibandingkan bebas karies.

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Background: Dental caries is a common disease worldwide. Saliva has a big role in oral cavity associated with dental caries. Total Antioxidant Capacity has a role to protect the body from any pathological condition. Objective: Analysing Total Antioxidant Capacity concentration of Early Childhood Caries and Caries Free saliva and its relation to OHI-S, dmf-t, and salivary flow rate and viscosity. Method: 33 stored saliva samples of children under 71 month old with early childhood caries and caries free tested using total antioxidant capacity assay kit. Result: There is a significant difference between Total Antioxidant Capacity concentration in saliva of caries free and early childhood caries children, there is a moderate linear positive correlation between Total Antioxidant Capacity concentration and dmf-t. There is no difference between Total Antioxidant Capacity concentration in saliva of children with good and moderate OHI-S, high and moderate salivary flow rate, and watery and thick saliva. Conclusion: Total Antioxidant Capacity concentration in saliva of early childhood caries children is higher than caries free.