Latar Belakang. Polifarmasi, pengobatan berpotensi tidak tepat (PIM),ketidakpatuhan terhadap pengobatan, dan interaksi obat merupakan permasalahanterkait obat pada usia lanjut dan berhubungan dengan sindrom geriatri danberbagai luaran klinis negatif.Tujuan. Mengetahui karakteristik pasien dan pengobatan yang didapatkannya,mengetahui proporsi polifarmasi, PIM, ketidakpatuhan terhadap pengobatan, daninteraksi obat pada pasien di Poliklinik Geriatri.Metode. Penelitian deskriptif ini dilakukan secara potong-lintang di Rumah SakitUmum Pusat Nasional Dr. Cipto Mangunkusumo. Sampel diambil secarakonsekutif. Melalui wawancara dan telaah rekam medik, data pasien yangdikumpulkan berupa usia, jenis kelamin, tingkat pendidikan, status sosial danekonomi, komorbiditas, pengkajian geriatri komprehensif, obat-obatan yangdikonsumsi pasien, PIM berdasarkan kriteria STOPP versi 2 dan Beers 2019,ketidakpatuhan pengobatan berdasarkan MAQ, dan interaksi obat berdasarkanLexi-Interact Online dari Lexicomp®.Hasil. Dari 101 subjek, didapatkan karakteristik berupa sebagian besar subjekberusia 70 – 79 tahun (57,43%), berpendidikan tinggi (41,58%), menikah(62,38%), tinggal dengan keluarga (87,13%), berpenghasilan di bawah UMR(56,44%), dan berobat dengan Jaminan Kesehatan Nasional (97,03%). Sebagianbesar tidak mengalami malnutrisi (78,22%), memiliki fungsi kognitif normal(87,13%), tidak menderita depresi (90,1%), status fungsional mandiri (64,36%),pre-frail (70,3%), dan indeks komorbiditas Charlson sedang (50,5%). Obatantihipertensi merupakan obat yang paling banyak diresepkan (88,12%), terdapat11,88% subjek mengkonsumsi obat tradisional. Seluruh subjek (100%) memilikimultimorbiditas, komorbid terbanyak adalah hipertensi (85,15%). Polifarmasiterjadi pada 86,14% subjek, PIM berdasarkan kriteria STOPP versi 2 terjadi pada30,69% subjek, sedangkan berdasarkan kriteria Beers 2019 terjadi pada 36,63%subjek. Ketidakpatuhan terhadap pengobatan terjadi pada 60,4% subjek, daninteraksi antar-obat terjadi pada 82,18% subjek.Kesimpulan. Sebagian besar pasien di Poliklinik Geriatri mengalami polifarmasi,namun hanya sebagian kecil yang mengandung obat berpotensi tidak tepat.Sebagian besar pasien tidak patuh terhadap pengobatan dan mengkonsumsi obatobatanyang mengandung potensi interaksi obat.

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Background. Polypharmacy, potentially inappropriate medicine (PIM), nonadherence

to treatment, and drug interactions are drug-related problems that often

occur in the elderly and are associated with geriatric syndrome and various

clinical outcomes so that it needs attention in administering drugs for elderly

patients. .

Aim. Knowing character of the patients and the treatment they received, looking

at polypharmacy, PIM, non-adherence to treatment, and drug interactions in

patients at the Geriatric Polyclinic.

Method. It is a cross-sectional study done in March - April 2020 at Dr. Cipto

Mangunkusumo. The subject selecting based on consecutive sampling. Subjects

are interviewed with questionnaires and review the patient's medical records to

obtain data on age, gender, education level, social and economic status,

comorbidities, comprehensive geriatric assessments, drugs consumed by patients,

PIM based on STOPP version 2 and Beers 2019 criteria, adherence of treatment

with MAQ, and drug interactions based on Lexi-Interact Online from Lexicomp®.

Result. Of the 101 subjects, most of the subjects were 70-79 years old (57.43%),

female (54.46%), highly educated (41.58%), married (62.38%), living with family

(87.13%), earning below the UMR (56.44%), and seeking treatment with the

National Health Insurance (97.03%). Most of them are not malnourished

(78.22%), have normal cognitive function (87.13%), do not suffer from

depression (90.1%), independent functional status (64.36%), pre-frail (70.3 %),

and have moderate Charlson's comorbidity index (50.5%). Anti-hypertensive

drugs were the most prescribed drug (88.12%), 11.88% of patients consumed

traditional medicine. All subjects (100%) had multimorbidity, the most common

comorbid was hypertension (85.15%). Polypharmacy occurred in 86.14% of

subjects, PIM based on the STOPP version 2 criteria occurred in 30.69% of

subjects, and based on Beers 2019 criteria occurred in 36.63% of subjects. Nonadherence

to treatment did occur in 60.4% of subjects, and drug interactions

occurred in 82.18% of subjects.

Conclusion. Most elderly patients in the Geriatric Polyclinic experience

polypharmacy, but only a small proportion of them contain PIM. Most of the

patients do not adhere to treatment, and take drugs that involve drug interactions.

Keywords. polypharmacy, PIM, medication non-compliance, drug interactions,

elderly, outpatient.