Keselamatan pasien merupakan prioritas utama dalam pelayanan kesehatan, terutama pada masa pandemi Corona virus disease 19 (Covid-19) ini. Tujuan penelitian adalah untuk menganalisis faktor-faktor yang berhubungan dengan implementasi pencapaian Sasaran Keselamatan Pasien (SKP) oleh perawat di rumah sakit rujukan Covid-19 pada masa pandemi. Penelitian menggunakan pendekatan kuantitatif dengan desain penelitian analitik dan rancangan cross-sectional. Sampel berjumlah 268 perawat yang bekerja di tiga rumah sakit di Jawa Timur. Hasil penelitian menunjukkan terdapat hubungan yang signifikan status pernikahan (p=0,03), budaya keselamatan (p<0,001), dan fungsi manajemen (p<0,001) dengan implementasi SKP. Sementara, faktor usia, masa kerja, jenis kelamin, pendidikan, jenjang karir, unit kerja, tipe rumah sakit, pelatihan keselamatan, stres kerja tidak berhubungan dengan implementasi pencapaian SKP (p>0,05). Hasil analisis menggunakan Structured Equation Model-Partial Least Square (SEM-PLS) juga mendapatkan budaya keselamatan aspek perbaikan organisasi merupakan variabel yang paling berhubungan secara signifikan dengan implementasi pencapaian SKP. Rekomendasi dari hasii penelitian ini yaitu meningkatkan budaya keselamatan dalam meningkatkan kualitas implementasi enam sasaran keselamatan pasien.

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Patient safety is a top priority in healthcare services, especially during the Coronavirus disease 19 (Covid-19) pandemic. The purpose of the study was to analyze the factors related to the implementation of the Patient Safety Goals (SKP) by nurses at the Covid-19 referral hospital during the pandemic. The study used a quantitative approach with an analytical research design and a cross-sectional design. The sample is 268 nurses who work in three hospitals in East Java. The results showed that there was a significant relationship between marital status (p=0.03), safety culture (p<0.001), and management function (p<0.001) with the implementation of SKP. Meanwhile, age, working period, gender, education, career path, work unit, type of hospital, safety training, work stress were not related to the implementation of SKP achievement (p>0.05). The analysis results using the Structured Equation Model-Partial Least Square (SEM-PLS) also found that safety culture in the aspect of organizational improvement is the variable that is most significantly related to the implementation of SKP achievement. Recommendations from the results of this study are to improve safety culture in improving the quality of implementation of the six patient safety goals.