Latar belakang: Cedera kepala merupakan kegawatan di bidang Neurologi yang sering menyebabkan kematian dan kecacatan. Prognosis yang dapat dibuat diawal terjadinya cedera kepala akan membantu klinisi dalam memberikan tatalaksana yang tepat. Penelitian faktor prognostik pada cedera kepala dengan luaran skor GOSE yang dilakukan dalam tiga waktu pemantauan yang berbeda belum pernah dilakukan di RSUPN. Cipto Mangunkusumo.Metode penelitian: Penelitian ini merupakan uji prognostik dengan disain kohort prospektif dan retrospektif untuk mengetahui faktor prognostik luaran GOSE pasien cedera kepala sedang dan berat pada hari 90 sebagai luaran primer, juga luaran pada hari 14 dan 30. Populasi yaitu pasien cedera kepala di RSUPN. Cipto Mangunkusumo selama bulan Oktober 2019- Maret 2021. Analisis data bivariat dengan chi-square dilanjutkan analisis multivariat dengan regresi logistik.Hasil: Dari 139 sampel cedera kepala sedang dan berat didapatkan data demografik yaitu 81.3% sampel merupakan laki-laki dan usia rerata 40±44. Didapatkan sebaran klinis, SKG 3-8 16 sampel (11.5%), hipotensi 20 sampel (14.4%), Hipoksia sebanyak 11 sampel (7.9%), Anemia sebanyak 13 sampel (9.4%), hiperglikemi sebanyak 30 sampel ( 21.6%), skor ISS > 24 sebanyak 6 sampel (4.3%), skor Rotterdam > 4 sebanyak 56 sampel (45.2%). Pupil tidak reaktif bilateral 3.6%, reaktif unilateral 7.2%, reaktif bilateral 89.2%Untuk luaran GOSE hari 90 sebagai luaran primer yaitu luaran baik 60.4% dan luaran buruk 39.6%. Luaran hari 30 luaran baik 46.8% dan luaran buruk 53.2%. Luaran fase awal yaitu hari 14 luaran baik 31.7% dan luara buruk 68.3%.Analisis multivariat didapatkan faktor yang signifikan mempengaruhi luaran pada hari 14 yaitu usia di atas 60 tahun dan skor Rotterdam > 4. Analisis multivariat luaran hari 30 tidak didapatkan faktor yang signifikan mempengaruhi luaran GOSE. Pada hari 90 didapatkan faktor yang signifikan mempengaruhi luaran GOSE yaitu hipotensi < 100 mmHg.Kesimpulan: Didapatkan faktor prognostik pada hari 14 yaitu usia dan skor Rotterdam dan faktor prognostik pada hari 90 yaitu hipotensi.

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Background: Brain injury is an emergency in Neurology that often causes death and disability. Prognosis that can be made early in the occurrence of head injury will assist clinicians in providing appropriate management. The study of prognostic factors in head injury with GOSE score outcome that was conducted in three different monitoring times had never been done in RSUPN. Cipto Mangunkusumo.

Research method: Prognostic test with a prospective and retrospective cohort design to determine the prognostic factors for GOSE outcome in moderate and severe brain injury patients on day 90 as the primary outcome, as well as outcomes on days 14 and 30. The population was brain injury patients at the RSUPN. Cipto Mangunkusumo during October 2019-March 2021. Bivariat analysis with chi-square was followed by multivariate analysis with logistic regression.

Results: 139 samples of moderate and severe brain injury, demographic data were obtained, 81.3% of the sample were male and the mean age was 40±44. Obtained clinical distribution, SKG 3-8 16 samples (11.5%), hypotension 20 samples (14.4%), Hypoxia in 11 samples (7.9%), Anemia in 13 samples (9.4%), hyperglycemia in 30 samples (21.6%), ISS score > 24 for 6 samples (4.3%), Rotterdam score > 4 for 56 samples (45.2%). Bilateral unreactive pupils 3.6%, unilateral reactive 7.2%, bilaterally reactive 89.2%

For the 90 day GOSE outcome as the primary outcome, 60.4% good outcome and 39.6% bad outcome. The 30 day output is 46.8% good and 53.2% bad. The output of the initial phase was on day 14, good outcome was 31.7% and bad outcome was 68.3%.

Multivariate analysis found that the factors that significantly affected the outcome on day 14 were age over 60 years and Rotterdam score > 4. Multivariate analysis on day 30 did not find any significant factor influencing the outcome of GOSE. On day 90, it was found that a significant factor affecting the outcome of GOSE was hypotension < 100 mmHg.

Conclusion: In patients with moderate and severe brain injury, there were different prognostic factors for monitoring GOSE outcomes on days 14, 30 and 90.