Tujuan: Menganalisis perbedaan microhardness dan flexural strength dentin saluran akar setelah paparan berbagai larutan irigasi endodontik regeneratif. Metode: Tiga puluh enam sampel dentin gigi manusia yang baru diekstraksi dibagi menjadi 6 kelompok yaitu 2 kelompok kontrol (NaCl 0,9%), 2 kelompok uji 1 diirigasi dengan 20 ml NaOCl 1,5% selama 5 menit – 3 ml NaCl 0,9% selama 3 menit – 20 ml EDTA 17% selama 5 menit, 2 kelompok uji 2 diirigasi dengan 20 ml NaOCl 1,5% selama 5 menit – 3 ml PBS 10% selama 3 menit – 20 ml EDTA 17% selama 5 menit – 3 ml PBS 10% selama 3 menit. Perubahan microhardness dan flexural strength dievaluasi dengan uji Vickers dan 3-Point Flexural Tester. Data dianalisis menggunakan One-Way ANOVA dan Tamhane. Hasil: Terdapat perbedaan bermakna antar kelompok uji 1 dan 2 dengan kelompok kontrol (One-Way ANOVA, p < 0,05). Berdasarkan uji Post Hoc (Tamhane, p<0,05) terdapat perbedaan bermakna microhardness dan flexural strength kelompok uji 2 dibandingkan kelompok uji 1, dengan nilai rerata lebih tinggi pada kelompok uji 2 terhadap kelompok uji lainnya. Kesimpulan: Kelompok uji 2 memiliki nilai microhardness dan flexural strength lebih baik sebagai bahan regenerasi endodontik regeneratif.

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Objective: To analyze the differences in microhardness and flexural strength of root canal dentin after exposure various regenerative endodontic irrigation solution.

Methods: Thirty-six dentine samples from fresh extracted were assigned to 6 groups, two groups as a control (NaCl 0,9%), two test groups 1 (20 ml NaOCl 1,5% for 5 min – 3 ml NaCl 0,9% for 3 min – 20 ml EDTA 17% for 5 min), two test groups 2 (20 ml NaOCl 1,5% for 5 min – 3 ml PBS 10% for 3 min – 20 ml EDTA 17% for 5 min – 3 ml PBS 10% for 3 min). The changing of microhardness and flexural strength were evaluated using Vickers and 3-point flexural tester. Data were analysed using One-Way ANOVA and Tamhane.

Result: There was significant difference between test groups 1 and 2 with control group (One-Way ANOVA, p < 0,05). Based on the Post hoc test (Tamhane, p < 0,05 ), showed significant difference in microhardness and flexural strength between group 2 and group 1, with higher mean in test group 2 compared to other test groups.

Conclusion: Test group 2 had better microhardness and flexural strength as regenerative endodontic irrigation.