Penelitian ini menggunakan metode literature review yang membahas mengenai faktor-faktor yang berhubungan dengan terjadinya infeksi Covid-19 pasca vaksinasi. Vaksinasi Covid-19 merupakan salah satu upaya dalam pemutusan rantai penularan Covid-19 dengan cara membentuk kekebalan pada tubuh manusia. Namun nyatanya, sejumlah orang dinyatakan positif Covid-19 padahal sudah mendapatkan dua dosis vaksin baik itu di Indonesia ataupun di luar negeri. Tujuan dari penulisan adalah untuk mengetahui apa saja faktor-faktor yang berhubungan dengan terjadinya infeksi Covid-19 pasca vaksinasi. Penelitian dilakukan menggunakan metode literature review dengan mencari artikel penelitian yang dipublikasi di tahun 2021. Semua informasi didapatkan melalui pencarian artikel yang telah terpublikasi dengan menggunakan akses online database yaitu Google Scholar, ProQuest, Scopus, dan Oxford Academic. Hasil peninjauan literatur didapatkan sembilan artikel penelitian yang dianalisis. Hasil penelitian didapatkan bahwa mutasi varian virus Covid-19 dan peningkatan kemampuan transmisi dari virus merupakan hal terbanyak yang ditemukan dari literature review serta ditemukan pengaruh pekerjaan terkait risiko terpaparnya virus Covid-19 dan perilaku individu sebagai hasil temuan literature review yang berpengaruh terhadap terjadinya infeksi Covid-19 walaupun sudah mendapatkan vaksinasi. Saran literature review untuk faktor-faktor yang berhubungan dengan terjadinya infeksi Covid-19 pasca vaksinasi adalah perlu bagi masyarakat dan setiap individu untuk tetap melakukan pencegahan dan pengendalian Covid-19. Pencegahan dan pengendaliannya melaksanakan protokol kesehatan 3M, 3T, dan mendukung pelaksanaan vaksinasi.

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This study uses a literature review method which discusses the factors associated with the occurrence of covid-19 infection post-vaccination. The Covid-19 vaccination is one of the efforts to break the chain of transmission of Covid-19 by forming immunity in the human body. But in fact, a number of people have tested positive for Covid-19 even though they have received two doses of the vaccine, both in Indonesia and abroad. The purpose of the writing is to find out what are the factors associated with the occurrence of covid-19 infection post-vaccination. The research was conducted using the literature review method by searching for some research articles published in 2021. All information was obtained through searching for published articles using online database access, namely Google Scholar, ProQuest, Scopus, and Oxford Academic. The results of the literature review showed that nine research articles were analyzed. The results of the study found that mutations of the Covid-19 virus variant and increased transmission ability of the virus were the most common things found from the literature review and found the influence of work related to the risk of exposure to the Covid-19 virus and individual behavior as a result of the literature review findings that affected the occurrence of Covid-19 infection 19 despite getting vaccinated. Suggestions for a literature review for factors associated with the occurrence of covid-19 infection postvaccination is that it is necessary for the community and every individual to continue to prevent and control Covid-19. Prevention and control implement the health protocols such as 3M, 3T, and support the implementation of vaccinations.