COVID-19 merupakan penyakit yang disebabkan oleh jenis virus corona baru, yaitu Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Sejak 11 Maret 2020, WHO menyatakan bahwa COVID-19 dikategorikan sebagai sebuah pandemi. Penularan COVID-19 dapat terjadi secara langsung maupun tidak langsung. Kepatuhan penerapan protokol kesehatan COVID-19 merupakan salah satu hal yang sangat penting dilakukan oleh seluruh lapisan masyarakat termasuk mahasiswa sehingga diharapkan nantinya dapat mengendalikan penyebaran COVID-19. Penelitian ini bertujuan untuk mengetahui faktor – faktor yang mempengaruhi kepatuhan penerapan protokol kesehatan COVID-19 pada Mahasiswa Rumpun Ilmu Kesehatan Universitas Indonesia angkatan 2017 – 2019. Studi cross sectional dilakukan kepada 443 responden yang diperoleh melalui purposive sampling, dengan proporsi responden perempuan sebesar 88,7% dan laki-laki sebesar 11,7%. Data dianalisis secara univariat dan bivariat dengan uji chi square. Hasil penelitian menunjukkan bahwa proporsi kepatuhan responden terhadap penerapan protokol kesehatan COVID-19 sebesar 52,1% ; terdapat hubungan yang signifikan antara persepsi manfaat, persepsi hambatan, persepsi kemampuan diri, informasi yang didapatkan, dan dukungan lingkungan sosial dengan kepatuhan penerapan protokol kesehatan COVID-19; dan tidak terdapat hubungan yang signifikan antara umur, jenis kelamin, pengetahuan terkait COVID-19, persepsi kerentanan, persepsi keparahan, dan riwayat COVID-19 dengan kepatuhan penerapan protokol kesehatan COVID-19. Optimalisasi progam pencegahan COVID-19 oleh pemerintah dan seluruh lapisan masyarakat dapat mengendalikan penyebaran COVID-19.

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COVID-19 is a disease caused by a new type of corona virus, namely Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Since the 11 th of March 2020, WHO has declared that COVID-19 is categorized as a pandemic. Transmission of COVID-19 can occur directly or indirectly. Compliance with the implementation of the COVID-19 health protocols is one of the most important things that must be done by all levels of society, including university students. The purpose of this study was to determine the factors that affect compliance with the implementation of the COVID-19 health protokolin the University of Indonesia Health Sciences Cluster Students University of Indonesia class of 2017 – 2019. A cross sectional study was conducted by recruiting 443 respondents obtained through purposive sampling, with the proportion of female respondents being 88.7. % and male by 11.7%. Data were analyzed by univariate and bivariate with chi square test. The results showed that the proportion of respondents compliance with the implementation of the COVID-19 health protokolwas 52.1%; there was a significant relationship between perceived benefits, perceived barriers, perceived self-efficacy, information obtained, and social environment support with compliance to the implementation of the COVID-19 health protocols; and there was no significant relationship between age, gender, knowledge related to COVID-19, perception of vulnerability, perception of severity, and history of COVID-19 with compliance to the implementation of the COVID-19 health protocols. Optimization of the COVID-19 prevention program by the government and all levels of society can control the spread of COVID-19.