Penelitian ini bertujuan menganalisis pengaruh aktivitas ekonomi regional melalui banyaknya perusahaan terhadap pariwisata domestik pada masa pandemi COVID-19, dengan memperhitungkan hubungan spasial antar provinsi di Indonesia. Analisis spasisal dilakukan dengan menggunakan Moran’s I test dan Spatial Durbin Model. Hasil penghitungan nilai Moran’s I signifikan positif, menunjukkan bahwa terdapat keterkaitan kunjungan wisnus antar provinsi. Variabel utama usaha dan kepadatan berpengaruh signifikan negatif, sedangkan variabel tenaga kerja berpengaruh signifikan positif terhadap jumlah kunjungan wisnus di suatu provinsi. Hasil penelitian menunjukkan bahwa daerah dengan aktivitas ekonomi regional tinggi kurang diminati wisatawan nusantara (wisnus) pada masa pandemi Covid-19 di Indonesia. Selain itu, faktor-faktor lain yang mempengaruhi pariwisata domestik adalah tenaga kerja dan kepadatan penduduk.

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This study aims to investigate the how the regional economic activity measured as the agglomeration of companies affects domestic tourism during the Covid-19 pandemic, taking into account the spatial relationship between provinces in Indonesia. Spatial analysis was carried out using Moran’s I test and Spatial Durbin Model. The value of Moran’s I significantly positive, indicating that there is a link of tourists visits between provinces. The main variables of companies and density have a significant negative, while the labor variable has a significant positive on the number of domestic tourist visiting in a province. The results confirm that areas with high regional economic activity were less attractive to domestic tourist during the Covid-19 pandemic in Indonesia. In addition, other factors that affect domestic tourism are labor and population density.