Senyawa turunan tiazolidin merupakan senyawa heterosiklik dengan atom nitrogen dan sulfur dalam struktur cincinnya yang dikenal memiliki aktivitas biologis, yaitu antioksidan, antitumor, anti-inflamasi, antimikorba, dan anti-hiperglikemia. Pada penelitian kali ini akan dilakukan sintesis senyawa turunan tiazolidin yang berasal dari 3- asetilpiridin dan memiliki subtituen aldehid aromatik dari senyawa sinamaldehid, benzaldehida, dan 4-hidroksi benzaldehida. Produk senyawa turunan tiazolidin ini diidentifikasi menggunakan KLT dan uji titik leleh, serta dikarakterisasi menggunakan spektrofotometer Ultraviolet-Visible (UV-Vis), Fourier Transform Infrared spectroscopy (FTIR), dan Liquid Chromatography Mass Spectrometry (LC-MS). Senyawa yang terbentuk dilakukan pengujian aktivitas antioksidan dengan menggunakan metode DPPH. Pada penelitian ini didapatkan produk 3-asetilpiridin tiosemikarbazon dengan persen rendemen sebesar 73,83%, 3-asetilpiridin tiazolidin-4-on sebesar 38,39%. turunan 3- asetilpiridin tiazolidin-4-on sinamaldehida sebesar 4,61%, turunan 3-asetilpiridin tiazolidin-4-on benzaldehida sebesar 15,82%, dan turunan 3-asetilpiridin tiazolidin-4-on 4-hidroksi benzaldehida sebesar 21,42%. Kemampuan antioksidan senyawa ditinjau dari nilai IC50 dimana senyawa 3-asetilpiridin tiazolidin-4-on sebesar 452,11 ppm, turunan 3-asetilpiridin tiazolidin-4-on sinamaldehida sebesar 1553,52 ppm, turunan 3- asetilpiridin tiazolidin-4-on benzaldehida sebesar 3484,42 ppm, dan turunan 3- asetilpiridin tiazolidin-4-on 4-hidroksi benzaldehida sebesar 1542,78 ppm.

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Thiazolidine derivative compounds are heterocyclic compounds with nitrogen and sulfur atom in their ring structure which are known to have biological activities, such as antioxidant, antitumor, anti-inflammatory, antimicrobial, and anti-hyperglycemic. In this study, the synthesis of thiazolidine derivatives derived from 3-acetylpyridine and aromatic aldehyde substituents from cinnamaldehyde, benzaldehyde, and 4-hydroxy benzaldehyde compounds will be carried out. Thiazolidine derivative product was identified using TLC and melting point test, and characterized using Ultraviolet-Visible (UV-Vis) spectrophotometer, Fourier Transform Infrared spectroscopy (FTIR), and Liquid Chromatography Mass Spectrometry (LC-MS). The compounds formed were tested for antioxidant activity using the DPPH method. In this study, 3-acetylpyridine thiosemicarbazone was obtained with a yield 73.83%, 3-acetylpyridine thiazolidine-4- one were 38.39%. the 3-acetylpyridine thiazolidine-4-one derivative of cinnamaldehyde were 4.61%, the 3-acetylpyridine thiazolidine-4-one benzaldehyde derivative were 15.82%, and the 3-acetylpyridine thiazolidine-4-one 4-hydroxy benzaldehyde derivative were 21.42 %. The antioxidant ability of the compound was assessed from the IC50 value where the 3-acetylpyridine thiazolidine-4-one compound was 452.11 ppm, 3- acetylpyridine thiazolidine-4-one derivative of cinnamaldehyde was 1553.52 ppm, 3- acetylpyridine thiazolidine-4-one derivative of benzaldehyde was 3484.42 ppm, and derivatives of 3-acetylpyridine thiazolidine-4-one 4-hydroxy benzaldehyde was 1542.78 ppm.