Pondok Pesantren berisiko menjadi klaster baru penularan COVID-19. Penelitian ini bertujuan untuk menggambarkan tingkat pengetahuan, sikap, dan keterampilan tentang pencegahan COVID-19 pada santri. Penelitian ini menggunakan studi deskriptif kuantitatif. Responden yang terlibat berjumlah 333 santri Pondok Pesantren X di Kabupaten Lebak dan diambil menggunakan stratified random sampling berdasarkan strata pendidikan yakni SMP dan SMA serta proportional sampling. Hasil dari penelitian ini menunjukkan rentan usia santri dari 12-18 tahun, tingkat pendidikan SMA (52%), santri berjenis kelamin perempuan (75,1%), tidak memiliki riwayat COVID-19 (72,4%), riwayat vaksinasi COVID-19 sampai dosis 2 (84,4%), dan sumber informasi dari Kiai/Ustad/Ustdzah/ Guru (31,8%), tingkat pengetahuan santri tentang Pencegahan COVID-19 tergolong baik (92,50%), sikap pencegahan COVID-19 baik (56,2%), dan keterampilan pencegahan COVID-19 yang baik (53,8%). Rekomendasi dari penelitian ini perlunya peningkatan peran Poskestren dan Kiai/Ustadz/stadzah dalam mengontrol penerapan pencegahan COVID-19 di Pondok Pesantren karena masih adanya pengetahuan, sikap dan keterampilan pencegahan COVID-19 yang kurang pada santri.

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Pondok Pesantren are at risk of becoming new clusters of COVID-19 transmission. The implementation of COVID-19 prevention is an important thing to do for the Pesantren community. The purpose of this research was to describe the level of knowledge, attitudes, and skills about preventing COVID-19 in santri. This research uses a quantitative descriptive study. The respondents involved were 333 santri of Pondok Pesantren X in Lebak Regency and were taken using stratified random sampling based on educational strata (SMP and SMA) and proportional sampling. The results of this study indicate that students are aged from 12-18 years old, high school education level (52%), female santri (75.1%), haven’t history of COVID-19 (72.4%), and history of COVID-19 vaccination up to dose 2 (84.4%), and sources of information from Kiai/Ustad/Ustdzah/Teachers (31.8%), the level knowledge of students about COVID-19 prevention is good (92.50%), the attitude of preventing COVID-19 is good (56.2%), and the skills of preventing COVID-19 is good (53.8%). Recommendation from this study are the need to increase the role of Poskestren and Kiai/Ustadz/stadzah in controlling the implementation of COVID-19 prevention in Islamic boarding schools because there is still a lack of knowledge, attitudes and skills to prevent COVID-19 in santri.