In keeping with the growing emphasis on psychiatry in the medical school curriculum, problem-based learning (PBL) offers students a unique patient-centred, multidisciplinary approach to study and the synthesis of knowledge.The new 2nd edition of Problem-Based Behavioral Science and Psychiatry integrates DSM-5 updates and diagnostic criteria, and is fully consistent with PBL models and methods. Building on the strengths of the popular and widely downloaded 1st edition, the 2nd edition is a clinically robust resource for both the medical and the behavioral science student. Over 40 contributors, many themselves graduates of PBL medical schools, apply problem-based learning methods to specific psychiatric disorders, general clinical issues, and bedrock physician skills such as the intake interview and treatment planning.The book’s fictional case vignettes illustrated typical patient scenarios, providing real-world context for content areas, and accompanying case diagrams show the relationships between patient behaviour and underlying neurobiological structures. Each student-friendly section ends with helpful review questions.