The book focuses on a vital area of biophysical research that has been—in the author’s view—substantively overlooked if not relegated, an area from within many of the needed breakthroughs are likely to sprout: the physics of biomolecular interfaces. The book advocates its paramount relevance to tackle some of the core problems in molecular biophysics in a unified systematic manner. To this effect, the book introduces powerful theoretical and computational resources and is set to inspire scientists at any level in their careers determined to address the major challenges in the field.