Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Pengaruh polivinil pirolidon terhadap laju disolusi furosemid dalam sistem dispersi padat

oleh Sutriyo, Rosmaladewi, Febrian Hevike Filosane ([Publisher not identified] , 2005)

 Abstrak

The research to accelerate furosemide, dissolution rate has been done through physical property modification by solid dispersion forming polyvinylpyrolidone (PVP) carrier with solvent method.Pure furosemide prosses property of being practically insoluble in water and has low biovailability .In current research,six weight ratio of furosemide to PVP being used are 1:1;1:3;1:5;1:9 and 1:15.Physical mixtures are made in equivalent weight ratio. The dissolution rate was examined by paddle method in phosphat buffer pH5,8.Solid dispersion caracterised with in vitro dissolution study,X -ray diffraction,infra red spectrophometer and differential scanning calometric.The result shows that solid dispersion of furosemide with PVP carrier is lugher compare to physical mixture dissolution rate and pure furosemide.The ratio furosemide to PVP who has the lughest dissolution rate is 1:15.The analyzing shows the existing of altering crystaline to amorphous state.

 File Digital: 1

 Metadata

Jenis Koleksi : Artikel Jurnal
No. Panggil : MIKE-II-1-Apr2005-30
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Penerbitan : [Place of publication not identified]: [Publisher not identified], 2005
Sumber Pengatalogan :
ISSN :
Majalah/Jurnal : Majalah Ilmu Kefarmasian
Volume : Vol. II (1) April 2005: 30-42
Tipe Konten :
Tipe Media :
Tipe Carrier :
Akses Elektronik :
Institusi Pemilik : Universitas Indonesia
Lokasi :
  • Ketersediaan
  • Ulasan
  • Sampul
No. Panggil No. Barkod Ketersediaan
MIKE-II-1-Apr2005-30 03-20-593882308 TERSEDIA
Ulasan:
Tidak ada ulasan pada koleksi ini: 90100
Cover